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Granulocyte Macrophage Progenitor Numbers in Peripheral Blood Stem Cell Autotransplantation

  • Chapter
Advances in haemapheresis

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 25))

Abstract

Autotransplantation using peripheral blood stem cells (PBSC) collected during the periods of rapid hematological recovery which occur in early remission from acute leukemia or after intensive chemotherapy produces a completely different pattern of hemopoietic reconstitution (HR) from that seen when unstimulated PBSC collected during stable hemopoiesis are used[1–4]. The significant differences include:

  1. 1)

    Recovery of neutrophils and platelets to save levels by day 9–14 after transplantation.

  2. 2)

    Trilineage bone marrow engraftment evident seven days after transplantation.

  3. 3)

    Bone marrow cellularity normal or near normal at 14 days after transplantation.

  4. 4)

    Blood counts may then fall temporarily for 2–6 weeks (in AML but not in other diseases) until approximately 8–12 weeks after PBSC autotransplantation when stable long term hemopoiesis becomes established.

This work has been supported by grants from the Anti-Cancer Foundation of the Universities of South Australia, the National Health and Medical Research Council of Australia, the Baxter Centre for Medical Research in Sydney and Baxter Healthcare, United States of America.

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Authors
  1. C. A. Juttner
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  2. L. B. To
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  3. D. N. Haylock
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  4. P. G. Dyson
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  5. G. W. Dart
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  6. J. Q. K. Ho
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  7. N. Horvath
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  8. K. F. Bradstock
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  9. A. Enno
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  10. R. E. Sage
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  11. J. Szer
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Editor information

Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga

  2. University Hospital Utrecht, The Netherlands

    L. Kater

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© 1991 Springer Science+Business Media Dordrecht

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Juttner, C.A. et al. (1991). Granulocyte Macrophage Progenitor Numbers in Peripheral Blood Stem Cell Autotransplantation. In: Sibinga, C.T.S., Kater, L. (eds) Advances in haemapheresis. Developments in Hematology and Immunology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3904-9_12

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  • DOI: https://doi.org/10.1007/978-1-4615-3904-9_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6742-0

  • Online ISBN: 978-1-4615-3904-9

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