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The Effect of Chronic Exposure to Clotting Factor Concentrates on the Immune System

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Coagulation and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 26))

Abstract

Abnormalities of immune function occur in hemophilic patients independently of HIV infection [1-3]. These abnormalities arise as a result of the treatment, since untreated hemophiliacs are unaffected. These defects develop during childhood and adolescence [4,5] but remain stable over long periods in adult life. Although abnormalities of almost every aspect of immune function have been described in treated hemophiliacs,they are milder than the immune defects observed in AIDS and are not associated with opportunist infection.

This work was supported by the Haemophilia Society, grant no. 431932, and the University of Liverpool grant no. RD5267.

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Authors
  1. C. R. M. Hay
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Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. Haemophila and Thrombosis Centre, Milan, Italy

    P. M. Mannucci

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© 1991 Springer Science+Business Media Dordrecht

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Hay, C.R.M. (1991). The Effect of Chronic Exposure to Clotting Factor Concentrates on the Immune System. In: Sibinga, C.T.S., Das, P.C., Mannucci, P.M. (eds) Coagulation and Blood Transfusion. Developments in Hematology and Immunology, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3900-1_22

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  • DOI: https://doi.org/10.1007/978-1-4615-3900-1_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6740-6

  • Online ISBN: 978-1-4615-3900-1

  • eBook Packages: Springer Book Archive

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