Skip to main content

Platelet Counting and Function Testing

  • Chapter
Coagulation and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 26))

  • 214 Accesses

Abstract

During the last two decades the demand for platelet concentrates (PC) required for treatment of thrombocytopenic patients receiving multiple transfusions of PC has been steadily growing. This demand has been met by increasing rate of preparation of PC using conventional methods as well as by developing novel techniques. As a consequence there has been a need to improve our understanding on functional changes of the platelet during processing and storage of PC and to develop methods suitable for quality monitoring of critical stages in that process.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. De Wolf JThM. Clinical efficacy of platelet concentrates: Survival, recovery and hemostatic capacity. In: Smit Sibinga CTh, Das PC, Mannucci PM (eds). Coagulation and blood transfusion. Dordrecht: Kluwer Academic Publ., 1991:159–63.

    Chapter  Google Scholar 

  2. Dacie JV, Lewis SM. Practical haematology. Edinburgh: Churchill Livingstone,1991:57–8.

    Google Scholar 

  3. McShine RL, Das PC, Smit Sibinga CTh, Brozovic B. Differences between the effects of EDTA and citrate anticoagulants on platelet count and mean platelet volume. Clin Lab Haematol 1990;12:227–85.

    Google Scholar 

  4. Harker LA, Zimmerman TS (eds). Measurement of platelet function. Edinburgh:Churchill Livingstone 1983.

    Google Scholar 

  5. Brozovic B (ed). The role of leukocyte depletion in blood transfusion practice.Oxford: Blackwell Scientific Publications, 1989.

    Google Scholar 

  6. Bateson EAJ. Cryopreservation of platelets: Investigation of factors affecting recovery and function of frozen and thawed platelets. PhD thesis. London, 1988.

    Google Scholar 

  7. Rock G, Swenson SD, Adams GA. Platelet storage in plasma free medium. Transfusion 1985;25:551–6.

    Article  PubMed  CAS  Google Scholar 

  8. McShine RL, Das PC, Smit Sibinga CTh, Brozovic B. Enhancement of aggregation response in stored platelets using artificial medium. Abstract. ISBT/AABB Joint Congress, Los Angeles 1990:S545.

    Google Scholar 

  9. Kunicki TJ, Tucelli M, Becker GA, Aster RG. A study of variables affecting the quality of platelets stored at room temperature. Transfusion 1975;15: 414–21.

    Article  PubMed  CAS  Google Scholar 

  10. Holme S, Murphy S. Quantitative measurements of platelet shape by light transmission studies; application to storage of platelets for transfusion. J Lab Clin Med 1978;92:53–63.

    PubMed  CAS  Google Scholar 

  11. Bellhouse MA, Ross I, Entwistle CC, Bellhouse BJ. Optical measurement of the viability of stored human platelets. Optics and Laser Technology 1985;Febr:27–30.

    Google Scholar 

  12. Kim BK, Baldini MG. The platelet response to hypotonic shock. Its value as an indicator of platelet viability after storage. Transfusion 1974; 14: 130–8.

    Article  PubMed  CAS  Google Scholar 

  13. Mannucci PM, Sharp AA. Platelet volume and shape in relation to aggregation and adhesion. Br J Haematol 1967;13:604–17.

    Article  PubMed  CAS  Google Scholar 

  14. Karpatkin S. Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume. Blood 1978;51:307–16.

    PubMed  CAS  Google Scholar 

  15. Frojmovic MM, Milton JG. Human platelet size, shape, and related functions in health and disease. Physiol Rev 1982;62:185–261.

    PubMed  CAS  Google Scholar 

  16. Martin J, Trowbridge A (eds). Platelet heterogeneity. Biology and pathology.Heidelberg: Springer-Verlag, 1990.

    Google Scholar 

  17. Holme S, Murphy S. Coulter counter and light transmission studies of platelets exposed to low temperature, ADP, EDTA and storage at 22°C. J Lab Clin Med 1980;96:481–93.

    Google Scholar 

  18. McShine RL. The organisation of techniques used for quality control of platelet concentrates within the blood transfusion service. MPhil thesis. London, 1990.

    Google Scholar 

  19. McShine RL, Das PC, Smit Sibinga CTh, Brozovic B. The effect of EDTA on platelet count and other platelet parameters in blood and blood components collected with CPDA-1. Vox Sang 1991 ;(in press).

    Google Scholar 

  20. Seghatchian MJ, Vickers M, Ip AHL, et al. Changes in the mean platelet volume and the quality control of platelet concentrates. Abstract. ISBT/AABB Joint Congress, Los Angeles 1990:S523.

    Google Scholar 

  21. Trowbridge EA, Reardon DM, Hutchinson D, Pickering C. The routine measurement of platelet volume: A comparison of light-scattering and aperture-impedance technologies. Clin Phys Physiol Meas 1985;6:221–38.

    Article  PubMed  CAS  Google Scholar 

  22. Tandy N, Cutts M, Brooker V, et al. Evaluation of storage characteristics of platelets collected using the Autopheresis C PlateletcellTM . Abstract. ISBT/AABB Joint Congress, Los Angeles 1990:S536.

    Google Scholar 

  23. Suvarov AV, Markosyan RA. Some mechanisms of the effect of EDTA on platelet aggregation. Bui Exp Biol Med 1981;91:651–3.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Brozovic, B., McShine, R.L. (1991). Platelet Counting and Function Testing. In: Sibinga, C.T.S., Das, P.C., Mannucci, P.M. (eds) Coagulation and Blood Transfusion. Developments in Hematology and Immunology, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3900-1_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3900-1_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6740-6

  • Online ISBN: 978-1-4615-3900-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics