Abstract
Seven patients with acute nonlymphocytic leukemia (ANLL) and three patients with acute lymphocytic leukemia (ALL) in first or second complete remission were treated by high-dose cyclophosphamide and total body irradiation followed by transfusion of autologous bone marrow. In eight cases, marrow cells were treated ex vivo by 4-hydroperoxycyclo-phosphamide (4-HC). Engraftment occurred in all 10 patients. One ANLL patient who received unpurged marrow relapsed at day 393, however, nine others remain in unmaintained complete remission with a median follow-up of 448 days post-transplant (range: 57+ to 1651+ days). These preliminary results suggest that 4-HC purged autologous bone marrow transplantation is effective for children with ANLL or ALL in first or second remission who have no human leukocyte antigen matched donor.
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© 1991 Springer Science+Business Media New York
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Ohira, M., Takayama, J. (1991). Autologous Bone Marrow Transplantation for Children with Leukemia. In: Kobayashi, N., Akera, T., Mizutani, S. (eds) Childhood Leukemia: Present Problems and Future Prospects. Developments in Oncology, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3898-1_20
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DOI: https://doi.org/10.1007/978-1-4615-3898-1_20
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