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Bone Marrow Transplantation in Children and Quality of Life in Long-Term Survivors

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Childhood Leukemia: Present Problems and Future Prospects

Part of the book series: Developments in Oncology ((DION,volume 65))

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Abstract

Allogeneic bone marrow transplantation (BMT) has been performed in 70 patients with hematological malignancies or other various diseases during the last seven years at Tokai University. The projected survival rates of HLA genotypically compatible marrow recipients were 100% for chronic myelogenous leukemia (N = 10), 81.5% for acute nonlymphocytic leukemia (N = 13), 37.6% for acute lymphocytic leukemia (N = 14), 40.0% for solid tumors (N = 5) and 100% for non-neoplastic diseases (N = 12). Survival rates of patients who received marrow grafts from donors other than HLA genotypically identical siblings were 18.8% for leukemia (N = 8) and 100% for non-neoplastic diseases (N = 6). The quality of life in pediatric long-term surviving marrow recipients has been good and acceptable in general. Profound common abnormalities among survivors are long-lasting hypogonadism due to radiation and subclinical impairment of lung function in the first several months post-BMT. About two thirds of children experienced a transient decrease in growth velocity in the immediate post-transplant period.

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Authors and Affiliations

  1. Department of Pediatrics, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259-11, Japan

    Shunichi Kato, Miharu Yabe, Hiromasa Yabe, Chidori Kubota, Rumi Mitsuda, Yasumasa Oh & Osamu Shinohara

Authors
  1. Shunichi Kato
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  2. Miharu Yabe
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  3. Hiromasa Yabe
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  4. Chidori Kubota
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  5. Rumi Mitsuda
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  6. Yasumasa Oh
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  7. Osamu Shinohara
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Consortia

Tokai Bone Marrow Transplant Team

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Editors and Affiliations

  1. National Children’s Hospital, 3-35-31 Taishido, Setagaya-ku, Tokyo 154, Japan

    Noboru Kobayashi

  2. The National Children’s Hospital Medical Research Center, Tokyo, Japan

    Tai Akera

  3. Department of Virology, The National Children’s Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154, Japan

    Shuki Mizutani

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© 1991 Springer Science+Business Media New York

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Kato, S. et al. (1991). Bone Marrow Transplantation in Children and Quality of Life in Long-Term Survivors. In: Kobayashi, N., Akera, T., Mizutani, S. (eds) Childhood Leukemia: Present Problems and Future Prospects. Developments in Oncology, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3898-1_19

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  • DOI: https://doi.org/10.1007/978-1-4615-3898-1_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6739-0

  • Online ISBN: 978-1-4615-3898-1

  • eBook Packages: Springer Book Archive

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