Abstract
Many patients presenting with soft tissue sarcoma have a poor prognosis as a consequence of the tendency of these tumours to invade extensively, recur locally, and metastasize hematogenously early in the course of the disease. Nevertheless most patients present without clinically evident metastases, and gains in survival will derive from improved local control and the elimination of micrometastases. Effective combination therapy utilizing surgery and radiotherapy has improved the functional outcome without compromizing local control of the primary tumor, particularly in soft tissue sarcomas of the extremities. Métastases, however, occur in up to half of the cases, even with adequate local control [1–3]. This chapter will update studies reviewed in the last volume of this series and discuss new relevant information and topics.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Suit HD: Patterns of failure after treatment of sarcoma of soft tissue by radical surgery or by conservative surgery and radiation. Cancer Treat Symp 2:241–246, 1983.
Potter DA, Glenn J, Kinsella T, Glatstein E, Lack EE, Restrepo C, White DE, Seipp CA, Wesley R, Rosenberg SA: Patterns of recurrence in patients with high-grade soft tissue sarcomas. J Clin Oncol 3:353–366, 1985.
Romsdahl MM, Lindberg RD, Martin RG: Patterns of failure after treatment of soft tissue sarcoma. Cancer Treat Symp 2:251–258, 1983.
Wilson RE, Wood WC, Lerner HL, Antman K, Amato D, Corson JM, Proppe K, Harmon D, Carey R, Greenberger J, Suit H: Doxorubicin chemotherapy in the treatment of soft tissue sarcoma: Combined results of two randomized trials. Arch Surg 121:1354–1359, 1986.
Eilber FR, Ciuliano AE, Huth JF, Morton DL: Adjuvant adriamycin in high-grade extremity soft tissue sarcoma: A randomized prospective trial. Proc Am Soc Clin Oncol 5:125, 1986.
Eilber FR, Giuliano AE, Huth JF, Morton DL: A randomized prospective trial using postoperative adjuvant chemotherapy (adriamycin) in high-grade extremity soft tissue sarcoma. Amer J Clin Oncol (CCT) 11:39–45, 1988.
Antman K, Amato D, Pilepich M, et al.: Preliminary results of a randomized Intergroup soft tissue sarcoma adjuvant trial of doxorubicin versus observation. In: Adjuvant therapy of cancer. Salmon VS (ed). Philadelphia: Grune and Stratton, p 725, 1987.
Baker LH: Adjuvant therapy for soft tissue sarcomas. In: Recent concepts in sarcoma treatment. Ryan JR, Baker LO (eds). Dordrecht, The Netherlands: Kluwer Academic Publishers, pp 131–136, 1988.
Alvegard TA: Adjuvant chemotherapy with adriamycin in high grade malignant soft tissue sarcoma: A Scandinavian randomized study. Proc Am Soc Clin Oncol 5:125, 1986.
Alvegard RA, Sigurdson H, Mouridsen H, Soiheim O, Unsgaard D, Ringborg U, Dahl O, Nordentoft AM, Blomqvist C, Rydholm A, Stener B, Ranstam J: Adjuvant chemotherapy with doxorubicin in high-grade soft tissue sarcoma: A randomized trial of the Scandinavian Sarcoma Group. J Clin Oncol 7:1504–1513, 1989.
Gherlinzoni F, Bacci G, Picci P, Lapanna R, Calderoni P, Lorenzi EG, Bernini M, Emiliani E, Barbieri E, Mormand A, Campanacci M: A randomized trial for the treatment of high grade soft tissue sarcomas of the extremities: Preliminary observations. J Clin Oncol 4:552–558, 1986.
Picci P, Bacci G, Gherlinzoni F, Capanna R, Mercuri M, Ruggieri P, Baldini N, Avella M, Pignatti G, Manfrini M: Results of a randomized trial for the treatment of localized soft tissue tumors (STS) of the extremities in adult patients. In: Recent concepts in sarcoma treatment. Ryan JR, Baker LO (eds). Dordrecht, The Netherlands: Kluwer Academic Publishers, pp 144–148, 1988.
Benjamin RS, Terjanian TO, Genoglio CJ, Barkley HT, Evans HC, Murphy WK, Martin RG: The importance of combination chemotherapy for adjuvant treatment of high risk patients with soft tissue sarcomas of the extremities. In: Adjuvant therapy of cancer V. New York: Grune and Stratton, pp 735–744, 1987.
Edmonson JH, Fleming TR, Ivins VC, Burgert EO, Souie EH, O’Connell MJ, Sim FH, Ahmann DL: Randomized study of systemic chemotherapy following complete excision of non-osseous sarcomas. J Clin Oncol 2:1390–1396, 1984.
Baker AR, Change AE, Glatstein E, Rosenberg SA: National Cancer Institute experience in the management of high grade extremity soft tissue sarcoma. In: Recent concepts in sarcoma treatment. Dordrecht, The Netherlands: Kluwer Academic Publishers, pp 123–130, 1988.
Chang AR, Kinsella R, Glatstein E, Baker AR, Sindecar WF, Lotze MT, Danforth DN, Sugarbaker PH, Lack EE, Steinberg SM, White DE, Rosenberg SA: Adjuvant chemotherapy for patients with high grade soft tissue sarcomas of the extremity. J Clin Oncol 6:1491–1500, 1988.
Bramwell VHC, Rouesse J, Santoro A, Buesa J, Somers R, Thomas D, Sylvester R, Pinedo HM: European experience of adjuvant chemotherapy for soft tissue sarcomas: Preliminary report of a randomized trial of cyclophosphamide, vincristine, doxorubicin and dacarbazine. Cancer Treat Symp 3:99–108, 1985.
Bramwell VHC, Rouesse J, Steward W, Santoro A, Buesa J, Schafford-Koops N, Wagener T, Somers R, Ruka W, Markham D, Burgers M, Van Unnik J, Comtesso G, Thomas D, Sylvester R, Pinedo H: European experience of adjuvant chemotherapy for soft tissue sarcoma: An interim report of a randomized trial of CYVADIC versus control. In: Recent concepts in sarcoma treatment. Dordrecht, The Netherlands: Kluwer Academic Publishers, pp 157–164, 1988.
Bramwell V, Rouesse J, Steward W, Santoro A, Buesa J, Thomas D, Sylvester R: Reduced rate of local recurrence following CYVADIC chemotherapy in localized soft tissue sarcoma: An EORTC randomized trial. Proc Am Soc Clin Oncol 8:320, 1989.
Bui NB, Maree D, Coindre JM, Bonichon F, Kantor G, Avril A, Ravaud A: First results of a prospective randomized study of CYVADIC adjuvant chemotherapy in adults with operable high risk soft tissue sarcoma. Proc Am Soc Clin Oncol 8:318, 1989.
Dresdale A, Bonow RO, Wesley R, Palmeri ST, Barr L, Mathison D, D’Abngelo T, Rosenberg SA: Prospective evaluation of doxorubicin-induced cardiomyopathy resulting from postsurgical adjuvant treatment of patients with soft tissue sarcomas. Cancer 52:51–60, 1983.
Ettinghausen SE, Bonow RO, Palmeri ST, Seipp CA, Steinberg SM, White DE, Rosenberg SA: Prospective study of cardiomyopathy induced by adjuvant doxorubicin therapy in patients with soft tissue sarcomas. Arch Surg 121:1445–1451, 1986.
Shamberger RC, Sherins RJ, Ziegler JL, Glatstein E, Rosenberg SA: Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma. J Natl Cancer Inst 67:1213–1218, 1981.
Shamberger RC, Sherins RJ, Rosenberg SA: The effects of postoperative adjuvant chemotherapy and radiotherapy in testicular function in men undergoing treatment for soft tissue sarcoma. Cancer 47:2368–2374, 1981.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mertens, W.C., Bramwell, V.H.C. (1991). Adjuvant Chemotherapy for Soft Tissue Sarcomas. In: Pinedo, H.M., Verweij, J., Suit, H.D. (eds) Soft Tissue Sarcomas: New Developments in the Multidisciplinary Approach to Treatment. Cancer Treatment and Research, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3896-7_8
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3896-7_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6738-3
Online ISBN: 978-1-4615-3896-7
eBook Packages: Springer Book Archive