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Part of the book series: Cancer Treatment and Research ((CTAR,volume 56))

Abstract

Soft tissue sarcomas have been defined as malignant tumors involving nonepithelial extraskeletal tissues of the body, exclusive of the reticuloendothelial system, glia, and supporting tissues of various parenchymal organs [1]. The soft tissues are represented by voluntary muscles, fat, and fibrous tissue, along with the vessels servicing these tissues [1]. By convention, the soft tissues include the peripheral nervous system because tumors arising from nerves present as soft tissue masses and pose similar problems in differential diagnosis and therapy [1]. Embryologically, the soft tissues are derived principally from mesoderm, with some contribution for ectoderm [1].

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References

  1. Enzinger FM, Weiss SW: General considerations. In: Soft tissue tumors, 2nd edition. Enzinger FM, Weiss SW (eds). St Louis: CV Mosby, pp 1–18, 1989.

    Google Scholar 

  2. Presant CA, Russell WO, Alexander RW, et al.: Soft tissue and bone sarcoma histopathol-ogy peer review: The frequency of disagreement in diagnosis and the need for second pathology opinions: The Southeastern Cancer Study Group experience. J Clin Oncol 4:1658–1661, 1986.

    PubMed  CAS  Google Scholar 

  3. Coindre JM, Trojani M, Contesso G, et al.: Reproducibility of a histopathologic grading system for adult soft tissue sarcomas. Cancer 58:306–309, 1986.

    Article  PubMed  CAS  Google Scholar 

  4. Miser JS, Triche TJ, Pritchard DJ, Kinsella T: Ewing’s sarcoma and the nonrhabdomyo-sarcoma soft tissue sarcomas of childhood. In: Principles and practice of pediatric oncology. Pizzo PA, Poplack DG (eds). Philadelphia: JB Lippincott, pp 678–688, 1989.

    Google Scholar 

  5. Simon MA, Enneking WF: The management of soft tissue sarcomas of the extremities. J Bone Joint Surg (Am) 58:317–327, 1976.

    CAS  Google Scholar 

  6. Weingrad DW, Rosenberg SA: Early lymphatic spread osteogenic and soft tissue sarcomas. Surgery 84:231–240, 1978.

    PubMed  CAS  Google Scholar 

  7. Pizzo PA, Horowitz ME, Poplack DG, Hays DM, Kun LE: Solid tumors of childhood. In: Cancer: Principles and practice of oncology, 3rd edition. DeVita VT, Jr, Hillman S, Rosenberg SA (eds). Philadelphia: JB Lippincott, pp 1612–1670, 1989.

    Google Scholar 

  8. Horowitz ME, Pratt CB, Webber BL, et al.: Therapy of childhood soft-tissue sarcomas other than rhabdomyosarcoma: A review of 62 cases treated at a single institution. J Clin Oncol 4:559–564, 1986.

    PubMed  CAS  Google Scholar 

  9. Chang AE, Rosenberg SA: Clinical evaluation and treatment of soft tissue sarcomas. In: Soft tissue tumors, 2nd edition. Enzinger FM, Weiss SW (eds). St Louis: CV Mosby, pp 19–42, 1988.

    Google Scholar 

  10. Chang AE, Rosenberg SA, Glatstein SA, Antman KH: Sarcomas of soft tissues. In: Cancer: Principles and practice of oncology, 3rd edition. DeVita VT, Jr, Hellman S, Rosenberg SA, (eds). Philadelphia: JB Lippincott, pp 1345–1398, 1989.

    Google Scholar 

  11. Mazeron JJ, Suit HD: Lymph nodes as sites of metastases from sarcomas of soft tissue. Cancer 60:1800, 1987.

    Google Scholar 

  12. Lawrence W, Jr, Hays DM, Heyn R, et al.: Lymphatic metastasis with childhood rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study. Cancer 60:910–915, 1987.

    Article  PubMed  Google Scholar 

  13. Kingston JE, McElwain TJ, Malpas JS: Childhood rhabdomyosarcoma: Experience of the Children’ps Solid Tumor Group. Br J Cancer 48:195–207, 1983.

    Article  PubMed  CAS  Google Scholar 

  14. Bunn PA, Jr, Ridgway EC: Paraneoplastic syndromes in cancer. In: Cancer: Principles and practice of oncology, 3rd edition. De Vita VT, Jr, Hellman S, Rosenberg SA (eds). Philadelphia: JB Lippincott, pp 1896–1940, 1989.

    Google Scholar 

  15. Lawrence W, Jr, Gehan EA, Hays DM, et al.: Prognostic significance of staging factors of the UICC staging system in childhood rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study (IRS-II). J Clin Oncol 5:46–54, 1987.

    PubMed  Google Scholar 

  16. Young JL, Jr, Miller RW: Incidence of malignant tumors in U.S. Children. J Pediatr 86:254, 1975.

    Google Scholar 

  17. Flamant F, Hill C: The improvement in survival associated with combined chemotherapy in childhood rhabdomyosarcoma: A historical comparison of 345 patients in the same center. Cancer 53:2417–2421, 1984.

    Article  PubMed  CAS  Google Scholar 

  18. Voute PA, Vos A, de Kraker J, et al.: Rhabdomyosarcoma: Chemotherapy and limited supplementary treatment program to avoid mutilation. Natl Cancer Inst Monogr 56:121-125, 1981.

    Google Scholar 

  19. Treuner J, Suder J, Gerein V, et al.: Behandlungsergebesse der nichtrabdomyosarcomatösen Weichteilmalegnome im Rahmen der CWI-81-Studie. Klin Pediatr 199:209–217, 1987.

    Article  CAS  Google Scholar 

  20. Pratt CB, Hustu HO, Kumar APM, et al.: Treatment of childhood rhabdomyosarcoma at St. Jude Children’s Research Hospital, 1962-1978. Natl Cancer Inst Monogr 56:93–101, 1981.

    PubMed  Google Scholar 

  21. Ghavimi F, Exelby PR, D’Angio GJ, et al.: Multidisciplinary treatment of embryonal rhabdomyosarcoma in children. Cancer 35:677–686, 1975.

    Article  PubMed  CAS  Google Scholar 

  22. Maurer HM, Gehan EA, Beltangady M, et al.: The Intergroup Rhabdomyosarcoma Study II. Cancer, in press.

    Google Scholar 

  23. Maurer H, Gehan E, Crist W, et al.: Intergroup rhabdomyosarcoma study (IRS) III: A preliminary report of overall outcome. Proc Amer Soc Clin Oncol 8:296, 1989.

    Google Scholar 

  24. Kun L, Etcubanas E, Pratt C, et al.: Treatment factors affecting local control in childhood rhabdomyosarcoma (Abstr). Proc Am Soc Clin Oncol 5:207, 1986.

    Google Scholar 

  25. Tefft M, Wharam M, Gehan E: Local and regional control by radiation in IRS II. Int J Rad Oncol Biol Phys 16(Suppl 1):159, 1988.

    Google Scholar 

  26. Crist WM, Raney RB, Ragab A, et al.: Intensive chemotherapy including cisplatin with and without etoposide for children with soft tissue sarcomas. Med Pediatr Oncol 15:51–57, 1987.

    Article  PubMed  CAS  Google Scholar 

  27. Rao BN, Etcubanas EE, Horowitz M, et al.: The results of conservative management of extremity soft tissue sarcomas in children. Proc Ann Meet Am Soc Clin Oncol 5:266, 1986.

    Google Scholar 

  28. Brizel DM, Weinstein H, Hunt M, et al.: Failure pattern and survival in childhood soft tissue sarcomas. Proc Amer Soc Therapeut Radiat Oncol 29:183, 1988.

    Google Scholar 

  29. Mandell LR, Ghavini F, Exelby P, Fuks Z: Preliminary results of alternating combination chemotherapy (CT) and hyperfractionated radiotherapy (HART) in advanced rhabdomyo-sarcoma (RMS). Int J Radiat Oncol Biol Phys 15:197–203, 1988.

    Article  PubMed  CAS  Google Scholar 

  30. Carli M, Perilongo GT, Paolucci P, et al.: Role of primary chemotherapy in childhood malignant mesenchymal tumors other than rhabdomyosarcoma. Preliminary results. Proc Am Soc Clin Oncol 5:208, 1986.

    Google Scholar 

  31. Olive D, Famant F, Rodary C, et al.: Responsiveness of nonrhabdomyosarcoma malignant mesenchymal tumors (NRMMT) to primary chemotherapy (CT). Proc XXth Meeting SIOP, Trondheim, Norway, p 118, 1988.

    Google Scholar 

  32. Rosenberg SA, Tepper J, Glatstein E, et al.: Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities. Cancer 52:424–434, 1983.

    Article  PubMed  CAS  Google Scholar 

  33. Antman K, Suit H, Amato D, et al.: Preliminary results of a randomized trial of adjuvant doxorubicin for sarcomas: Lack of apparent difference between treatment groups. J Clin Oncol 2:601–608, 1984.

    PubMed  CAS  Google Scholar 

  34. Suit HD, Manken HJ, Schiller AL, et al.: Results of treatment of sarcomas of soft tissue by radiation and surgery at Massachusetts General Hospital. Cancer Treat Symp 3:43–47, 1985.

    Google Scholar 

  35. Bramwell VH, Mouridsen HT, Santoro A, et al.: Cyclophosphamide versus ifosfamide: Final report of a randomized Phase II trial in adult soft tissue sarcomas. Eur J Cancer Clin Oncol 23:311, 1987.

    Google Scholar 

  36. Stuart-Harris R, Harper PG, Kaye SB, Willshaw E: High-dose ifosfamide by infusion with mesna in advanced soft tissue sarcoma. Cancer Treat Rev 10(Suppl A):163–164, 1983.

    Article  PubMed  Google Scholar 

  37. Suit HD: Patterns of failure after treatment of sarcoma of soft tissue by radical surgery or by conservative surgery and radiation. Cancer Treat Symp 2:241–246, 1983.

    Google Scholar 

  38. Potter DA, Glenn J, Kinsella T, et al.: Patterns of recurrence in patients with high-grade soft-tissue sarcomas. J Clin Oncol 3:353–366, 1985.

    PubMed  CAS  Google Scholar 

  39. Collin C, Godbold J, Hajdu S, Brennan M: Localized extremity soft tissue sarcoma: An analysis of factors affecting survival. J Clin Oncol 5:601–612, 1987.

    PubMed  CAS  Google Scholar 

  40. Roth JA, Putnam JB, Jr, Wesley MN, Rosenberg SA: Differing determinants of prognosis following resection of pulmonary metastasis from osteogenic and soft tissue sarcomas. Cancer 55:1361–1366, 1988.

    Article  Google Scholar 

  41. Ueda T, Aozasa K, Tsujimoto M, et al.: Multivariate analysis for clinical prognostic factors in 163 patients with soft tissue sarcoma. Cancer 62:1444–1450, 1988.

    Article  PubMed  CAS  Google Scholar 

  42. Mandard AM, Petiot JF, Marnay J, et al.: Prognostic factors in soft tissue sarcomas: A multivariate analysis of 109 cases. Cancer 63:1437–1451, 1989.

    Article  PubMed  CAS  Google Scholar 

  43. Shiraki M, Enterline HT, Brooks JJ, et al.: Pathologic analysis of advanced adult soft tissue sarcomas, bone sarcomas and mesotheliomas. The Eastern Cooperative Oncology Group (ECOG) experience. Cancer 64:484–490, 1989.

    Article  PubMed  CAS  Google Scholar 

  44. Eilber FR, Morton DL, Eckardt J, et al.: Limb salvage for skeletal and soft tissue sarcomas: Multidisciplinary preoperative therapy. Cancer 53:2579–2584, 1984.

    Article  PubMed  CAS  Google Scholar 

  45. Lindberg RD, Martin RG, Romsdahl MM, Barkley HT, Jr: Conservative surgery and postoperative radiotherapy in 300 adults with soft tissue sarcomas. Cancer 47:2391–2397, 1981.

    Article  PubMed  CAS  Google Scholar 

  46. Slater JD, McNeese MD, Peters LJ: Radiation therapy for unresectable soft tissue sarcomas. Int J Radiat Oncol Biol Phys 12:1729–1734, 1986.

    Article  PubMed  CAS  Google Scholar 

  47. Suit HD, Maukin HJ, Wood WC, Proppe KH: Preoperative, intraoperative, and postoperative radiation in the treatment of primary soft tissue sarcoma. Cancer 55:2659–2667, 1985.

    Article  PubMed  CAS  Google Scholar 

  48. Fontanesi J, Kun L, Pao W, et al.: Brachytherapy as primary or “boost” irradiation in 18 children with solid tumors. Int J Endocurie Therapy/Hyperthermia Oncol, submitted.

    Google Scholar 

  49. Curran WJ, Jr, Littman P, Raney RB: Interstitial radiation therapy in the treatment of childhood soft-tissue sarcomas. Int J Radiat Oncol Biol Phys 14:169–174, 1988.

    Article  PubMed  Google Scholar 

  50. Knight PJ, Doornbos JF, Rosen D, et al.: The use of interstitial radiation therapy in the treatment of persistent, localized, and unresectable cancer in children. Cancer 57:951–954, 1986.

    Article  PubMed  CAS  Google Scholar 

  51. Pratt C, James DH, Holton CP, Pinkel D: Combination therapy including vincristine for malignant solid tumors in children. Cancer Chemother Rep 52:489–495, 1968.

    PubMed  CAS  Google Scholar 

  52. Pinkel D: Cyclophosphamide in children with cancer. Cancer 15:42–49, 1962.

    Article  PubMed  CAS  Google Scholar 

  53. Pinkel D: Actinomycin D in childhood cancer: A preliminary report. Pediatrics 23:342–347, 1959.

    PubMed  CAS  Google Scholar 

  54. Gottleib JA, Baker LH, O’Bryan RM, et al.: Adriamycin (NSC-123127) used alone and in combination for soft tissue and bony sarcomas. Cancer Chemother Rep 6(Pt 3):271–282, 1975.

    Google Scholar 

  55. Tan C, Rosen G, Ghavimi F, et al.: Adriamycin (NSC-123127) in pediatric malignancies. Cancer Chemother Rep 6(Pt 3):259–266, 1975.

    Google Scholar 

  56. Gottleib JA, Benjamin RS, Baker LM, et al.: Role of DTIC (NSC-45388) in the chemotherapy of sarcomas. Cancer Treat Rep 60:199–203, 1976.

    Google Scholar 

  57. Pratt CB, Hayes FA, Green AA, et al.: Pharmacokinetic evaluation of cisplatin in children with malignant solid tumors. A phase II study. Cancer Treat Rep 65:1021–1026, 1981.

    CAS  Google Scholar 

  58. O’Dwyer PJ, Leyland-Jones B, Alonso MT, et al.: Etoposide (VP-16,213): Current status of an active anticancer drug. N Engl J Med 312:692–700, 1985.

    Article  PubMed  Google Scholar 

  59. Magrath I, Sandlund J, Raynor A, et al.: A phase II study of ifosfamide in the treatment of recurrent sarcomas in young people. Cancer Chemother Pharmacol 18(Suppl 2):S25–S28, 1985.

    Google Scholar 

  60. Pratt CB, Douglass EC, Goren MP, et al.: Clinical studies of ifosfamide/mesna at St. Jude Children’s Research Hospital, 1983-1988. Semin Oncol 16(Suppl 3):51–55, 1989.

    PubMed  CAS  Google Scholar 

  61. Grier HE, Perez-Atayde AR, Weinstein HJ: Chemotherapy for inoperable infantile fibro-sarcoma. Cancer 56:1507–1510, 1985.

    Article  PubMed  CAS  Google Scholar 

  62. Horowitz M, Balis F, Pastakia B, et al.: Integration of ifosfamide and VP-16 (IE) into the frontline therapy of pediatric sarcomas (PS). Proc Ann Meet Am Soc Clin Oncol 7:260, 1988.

    Google Scholar 

  63. Castello MA, Clerico A, Jenkner A, Dominici C: High-dose carboplatin and etoposide in children with malignant solid tumors. Proc XXth Meeting SIOP, Trondheim, Norway, p 195, 1988.

    Google Scholar 

  64. Miser JS, Kinsella TJ, Triche TJ, et al.: Ifosfamide with Mesna uroprotection and etoposide: An effective regimen in the treatment of recurrent sarcomas and other tumors of children and young adults. J Clin Oncol 5:1191–1198, 1987.

    PubMed  CAS  Google Scholar 

  65. Edmonson JH, Fleming TR, Ivins JC, et al.: Randomized study of systemic chemotherapy following complete excision of non-osseous sarcoma. J Clin Oncol 2:1390–1396, 1984.

    PubMed  CAS  Google Scholar 

  66. de Paula U, Suit HD, Harmon D: Adjuvant chemotherapy in clinical stage M0 sarcoma of soft tissue. Cancer 62:1907–1911, 1988.

    Article  PubMed  Google Scholar 

  67. Flamant F, Rodary C, Rey A, Praquin MT: Preliminary report on the SIOP protocol for malignant mesenchymal tumors. Proc XVIIth Meeting SIOP, Venice, Italy, pp 81–84, 1985.

    Google Scholar 

  68. Kung FH, Pratt CD, Krischer JP: Ifosfamide and VP-16 in the treatment of recurrent malignant solid tumors of childhood. Proc Ann Meet Am Soc Clin Oncol 8:301, 1989.

    Google Scholar 

  69. Stout AP: Fibrosarcoma in infants and children. Cancer 5:1028–1040, 1962.

    Article  Google Scholar 

  70. Soule EH, Pritchard DJ: Fibrosarcoma of infants and children: A review of 110 cases. Cancer 40:1711–1721, 1977.

    Article  PubMed  CAS  Google Scholar 

  71. Ninane J, Gosseye S, Panteon E, et al.: Congenital fibrosarcoma: Preoperative chemotherapy and conservative surgery. Cancer 58:1400–1406, 1986.

    Article  PubMed  CAS  Google Scholar 

  72. Blocker S, Koenig J, Ternberg J: Congenital fibrosarcoma. J. Pediatr Surg 22:665–670, 1987.

    Article  PubMed  CAS  Google Scholar 

  73. Gansar GF, Krementz ET: Desmoid tumors: Experience with new modes of therapy. South Med J 81:794–796, 1988.

    Article  PubMed  CAS  Google Scholar 

  74. Raney RB: Synovial sarcoma. Med Pediatr Oncol 9:41–45, 1981.

    Article  Google Scholar 

  75. Kauffman SL, Stout AP: Hemangiopericytoma in children. Cancer 13:695–710, 1960.

    Article  PubMed  CAS  Google Scholar 

  76. Shmookler BM, Enzinger FM: Juvenile liposarcoma: An analysis of 15 cases. Am J Clin Pathol 133:245–246, 1982.

    Google Scholar 

  77. Weiss SW, Enzinger FM: Malignant fibrous histiocytoma: An analysis of 200 cases. Cancer 41:2250–2266, 1978.

    Article  PubMed  CAS  Google Scholar 

  78. Raney RB, Allen A, O’Neill J, et al.: Malignant fibrous histiocytoma of soft tissue in childhood. Cancer 57:2198–2201, 1986.

    Article  PubMed  Google Scholar 

  79. Mayer CMH, Favara BE, Holton CP, Rainer G: Malignant mesenchymoma in infants. Am J Dis Child 128:847–850, 1974.

    PubMed  CAS  Google Scholar 

  80. Ducatman BS, Scheithauer BW, Piepgras DG, et al.: Malignant peripheral nerve sheath tumors: A clinicopathologic study of 120 cases. Cancer 57:2006–2021, 1986.

    Article  PubMed  CAS  Google Scholar 

  81. Raney RB, Schnaufer L, Zeigler M, et al.: Treatment of children with neurogenic sarcoma. Cancer 59:1–5, 1987.

    Article  PubMed  CAS  Google Scholar 

  82. Enzinger FM, Weiss SW: Malignant tumors of uncertain histogenesis. In: Soft tissue tumors, 2nd edition. Enzinger FM, Weiss SW, (eds). St Louis: CV Mosby, pp 929–965, 1988.

    Google Scholar 

  83. Nakashima Y, Unni KK, Shives TC, et al.: Mesenchymal chondrosarcoma of bone and soft tissue: A review of 111 cases. Cancer 57:2444–2453, 1986.

    Article  PubMed  CAS  Google Scholar 

  84. Chase DR, Enzinger FM: Epithelioid sarcoma: Diagnosis, prognostic indications and treatment. Am J Surg Pathd 9:241–263, 1985.

    Article  CAS  Google Scholar 

  85. Kawamoto EH, Weidner N, Agostini RM, Jr, Jaffe R: Malignant ectomesenchymoma of soft tissue: Report of 2 cases and review of the literature. Cancer 59:1791–1802, 1987.

    Article  PubMed  CAS  Google Scholar 

  86. Soule EH, Newton W, Moon TE, Tefft M: Extraskeletal Ewing’s sarcoma. Cancer 42:259–264, 1968.

    Article  Google Scholar 

  87. Askin FB, Rosai J, Sibley RK, et al.: Malignant small cell tumor of the thoracopulmonary region in childhood: A distinctive clinicopathologic entity of uncertain histogenesis. Cancer 43:2438–2451, 1979.

    Article  PubMed  CAS  Google Scholar 

  88. Llombart-Bosch A, Lacombe MJ, Contesso G, Peydro-Olaya A: Small round blue cell sarcoma of bone mimicking atypical Ewing’s sarcoma with neuroectodermal features. Cancer 60:1570–1582, 1987.

    Article  PubMed  CAS  Google Scholar 

  89. Shimada H, Newton W, Soule E, et al.: Pathologic features of extraosseous Ewing’s sarcoma. Hum Pathol 19:422–453, 1988.

    Article  Google Scholar 

  90. Cavazzana AD, Ninfo V, Montesco M, et al.: Peripheral neuroepithelioma: Morphologic and immunologic criteria for diagnosis (Abstr). Mod Pathol 1:17, 1988.

    Google Scholar 

  91. Marina NM, Etcubanas E, Parham D, et al.: Peripheral primitive neuroectodermal tumor (peripheral neuroepithelioma) in children: A review of the St. Jude experience and controversies in diagnosis and management. Cancer 64:1952–1960, 1989.

    Article  PubMed  CAS  Google Scholar 

  92. Laskin WB, Silverman TA, Enzinger FM: Postradiation soft tissue sarcomas: An analysis of 53 cases. Cancer 62:2330–2340, 1988.

    Article  PubMed  CAS  Google Scholar 

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Pratt, C.B., Kun, L.E. (1991). Soft Tissue Sarcomas of Children. In: Pinedo, H.M., Verweij, J., Suit, H.D. (eds) Soft Tissue Sarcomas: New Developments in the Multidisciplinary Approach to Treatment. Cancer Treatment and Research, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3896-7_11

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