Abstract
A mild tubulointerstitial nephritis can be seen in immunologicallyquiescent renal allografts as a result of an ongoing immunological attack. More severe lesions are observed during acute cellular rejection, where CD8+ lymphocytes and macrophages predominate. The use of cyclosporin can also induce tubulo-interstitial nephritis. The drug may produce reversible vasoconstriction, tubular damage and arteriolopathy with irreversible interstitial fibrosis. Appropriate adjustements of CsA dosage are mandatory to prevent progressive graft dysfunction.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Fuggle S.V., Mc Whinnie D.L., Morris P.J. Transplantation 44:214–220,1987.
Bishop G.A., Hall B.M., Duggin G.G., Horvath J.S., Sheil A.G.R., Tiller D.J. Kidney Int. 29:708–717,1986.
Croker B.P., Salomon D.R. In: Renal Pathology (eds C.C. Tisher and B.M. Brenner) Lippincott, Philadelphia, 1989, pp.1518–1554.
Platt J.L., Ferguson R.M., Sibley R.K., Gajl-Peczalska K.J., Michael A.F. Transplantation 36:343–346,1983.
Waltzer W.C., Miller F., Arnold A., Anaise D., Rapaport F.T. Transplantation 43:100–105,1987.
Hancock W.W., Thomson N.M., Atkins R.C. Transpl. Proc. 15:352–355,1983.
Mihatsch M.J., Ryffel B., Gudat F., Thiel G. In: Renal Pathology (eds C.C. Tisher and B.M. Brenner) Lippincott, Philadelphia, 1989, pp. 1555–1586.
Kahan B.D. N. Engl. J. Med. 321:1725–1738,1989.
Canadian Multicentre Transplant Study Group. N. Engl. J. Med. 309:809–815,1983.
Novick A.C., Ho-Hsieh H., Steinmuller D., Streem S.B., Cunningham R.J., Steinhilberg D., Goormastic M., Buszta C. Transplantation 42;2:154–158,1986.
Ponticelli C., De Vecchi A., Egidi F., Tarantino A., Montagnino G., Berardinelli L., Vegeto A. Transpl. Proc. 17(suppl 2):61–64, 1985.
Flechner S.M., Payne W.D.,Van Buren C., Kerman R., Kahan B.D. Transplantation 36;3:268–272,1983.
Farnsworth A., Hall B.M., Kirwan G.A., Bishop G.A., Duggin G.C., Goodman B., Norvath J., Johnson J., Ng A., Sheil A.G.R., Tiller D.J. Transplant. Proc. 15(suppl.1):636–638,1983.
Sawaya B., Provenzano R., Kupin W.L., Venkat K.K. Am. J. Kidney Dis. 12:534–537,1988.
Myers B.D., Sibley R., Newton L., Tomlanovich S.J., Boshkos C., Stinson E., Luetscher J.A., Whitney D.J., Krasny D., Coplon N.S.,Perlroth M.G. Kidney Int. 33;6:590–600,1988.
Austin III H.A., Palestine A.G., Sabnis S., Balow J.E., Preuss H. G., Nussenblatt R.B., Antonovych T.T. AM. J. Nephrol. 9:392–402, 1989.
Lewis R.M., Jenney R.P., Golden D.L., Kerr N.B., Van Buren C.T., Kerman R.H., Kahan B.D. Transplantation 47;2:266–272,1989.
Land W. Transpl. Proc. 20:73–77,1988.
Shih W., Hines W.H., Neilson E.G. Kidney Int 33:1113–1118,1988.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ponticelli, C., Banfi, G. (1991). Tubulo-Interstitial Lesions in Renal Allograft. In: Amerio, A., Coratelli, P., Massry, S.G. (eds) Tubulo-Interstitial Nephropathies. Developments in Nephrology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3892-9_20
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3892-9_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6736-9
Online ISBN: 978-1-4615-3892-9
eBook Packages: Springer Book Archive