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Fatty Acid Cyclooxygenase Metabolism of Arachidonic Acid in Human Tumor Cells

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Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

Part of the book series: Developments in Oncology ((DION,volume 67))

Abstract

The prostaglandins, leukotrienes and related eicosanoids have been implicated as mediators in human malignant disease, particularly in cellular events related to tumor metastasis, cell proliferation, tumor promotion and host immunoregulation (1–23). There is substantial evidence that human tumor cells may synthesize significant quantities of prostaglandins. Elevated production of prostaglandin E2 (PGE2) has been demonstrated in lung cancer patients in vivo (24,25). Other studies have shown that prostanoid biosynthesis is elevated in human tumor tissues in comparison with production in normal human tissues (26–28) and that cultured human tumor cells synthesize significant quantities of prostanoids (29–32). In the present studies, the profiles of prostanoid biosynthesis from endogenous arachidonic acid in 55 established cell lines derived from human tumors of the colon, lung, prostate, ovary, kidney, and the central nervous system were determined. The objective of these studies was the determination of PGH synthase activity in diverse histological classes of human tumor cells in order to discern whether fatty acid cyclooxygenase metabolism of arachidonic acid may be uniquely characteristic of certain histological classes of human tumors.

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Authors and Affiliations

  1. Program Development Research Group, Division of Cancer Treatment, National Cancer Institute, Bldg. 560, Rm. 32-60, Frederick, MD, 21701-1013, USA

    W. C. Hubbard, M. C. Alley, T. L. McLemore & M. R. Boyd

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  1. W. C. Hubbard
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  2. M. C. Alley
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  3. T. L. McLemore
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  4. M. R. Boyd
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, Detroit, MI, USA

    Kenneth V. Honn

  2. Department of Biochemistry, Vanderbilt University, Nashville, TN, USA

    Lawrence J. Marnett

  3. Department of Gynecological Endocrinology Klinikum Steglitz, Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA

    Thomas L. Walden Jr.

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© 1991 Springer Science+Business Media New York

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Hubbard, W.C., Alley, M.C., McLemore, T.L., Boyd, M.R. (1991). Fatty Acid Cyclooxygenase Metabolism of Arachidonic Acid in Human Tumor Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. Developments in Oncology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3874-5_5

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  • DOI: https://doi.org/10.1007/978-1-4615-3874-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6727-7

  • Online ISBN: 978-1-4615-3874-5

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