Abstract
The post transcriptional modification of tRNA whereby a guanine residue in the first position of the anticodon of certain tRNAs is excised and replaced by queuine occurs to a lesser extent in rapidly dividing cells than in quiescent cells. In this report we show that in the sub-lethally irradiated mouse even though the spleen increased seven fold in weight during the post-irradiation period of recovery there was only a slight increase in the (q-) tRNA. In dogs the bone marrow tRNAHis is completely (q-) however, the spleen tRNA is virtually 100% (q+). These results suggest that the presence of queuine has special importance in the metabolism of the spleen.
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Farkas, W.R., Szabo, L., Walden, T.L. (1991). The Transfer RNAs of the Irradiated Mouse Spleen Contain Queuine. In: Honn, K.V., Marnett, L.J., Nigam, S., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. Developments in Oncology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3874-5_26
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DOI: https://doi.org/10.1007/978-1-4615-3874-5_26
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