Leukotriene Production by Gamma Irradiated Macrophage Cells

Hupp, E. W.; Hajibeigi, A.; Hardcastle, J. E.

doi:10.1007/978-1-4615-3874-5_24

E. W. Hupp⁵,
A. Hajibeigi⁵ &
J. E. Hardcastle⁶

Part of the book series: Developments in Oncology ((DION,volume 67))

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Abstract

Irradiation of tissues and cells can liberate arachidonic acid from the phospholipids, which can then be metabolized to prostaglandins (1,2). Also, whole body gamma irradiation of animals causes significant increases in the levels of the prostaglandins and other cyclooxygenase metabolites (3,4). The release of arachidonic acid may be caused by radiation induced activation of phospholipase A₂ (2,5). Subsequent metabolism of arachidonic acid may be initiated by a radiation induced free radical mechanism and lipid peroxidation (2,5).

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Authors and Affiliations

Department of Biology, Texas Woman’s University, Denton, Texas, 76204, USA
E. W. Hupp & A. Hajibeigi
Department of Chemistry, Texas Woman’s University, Denton, Texas, 76204, USA
J. E. Hardcastle

Authors

E. W. Hupp
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A. Hajibeigi
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J. E. Hardcastle
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Editor information

Editors and Affiliations

Department of Radiation Oncology, Wayne State University, Detroit, MI, USA
Kenneth V. Honn
Department of Biochemistry, Vanderbilt University, Nashville, TN, USA
Lawrence J. Marnett
Department of Gynecological Endocrinology Klinikum Steglitz, Free University Berlin, Berlin, Germany
Santosh Nigam
Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA
Thomas L. Walden Jr.

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Hupp, E.W., Hajibeigi, A., Hardcastle, J.E. (1991). Leukotriene Production by Gamma Irradiated Macrophage Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. Developments in Oncology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3874-5_24

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DOI: https://doi.org/10.1007/978-1-4615-3874-5_24
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6727-7
Online ISBN: 978-1-4615-3874-5
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