Abstract
Membrane fusion is an essential step in the infection cycle of enveloped viruses. Fusion may occur with the plasma membrane or may occur by endocytosis of the virion followed by acidification and subsequent pH-induced fusion. Enveloped viruses possess an outer limiting membrane containing glycoproteins responsible for recognition of the target cell and mediation of the fusion event. Fusion may be facilitated by a dedicated protein, such as the F protein of Sendai, or the ability to facilitate fusion and the binding of the virion to the target membrane may involve a single protein species. Fusion of the viral envelope with the target membrane allows the entry of the viral genome and initiation of replication. At present an adequate understanding of the mechanism of the viral membrane fusion process is lacking.
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Yeagle, P.L., Kelsey, D.R., Flanagan, T.D., Young, J. (1991). Inhibition of Sendai Virus Fusion and Phospholipid Vesicle Fusion: Implications for the Pathway of Membrane Fusion. In: Ohki, S. (eds) Cell and Model Membrane Interactions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3854-7_10
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DOI: https://doi.org/10.1007/978-1-4615-3854-7_10
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