Abstract
Much of the toxicity, including genetic damage caused by ionising radiation (1) and chemicals such as anti-tumour antibiotics (2) is mediated by active forms of oxygen, particularly oxygen derived radicals. Active oxygen species are also produced by a wide variety of physiological processes in which enzymes catalyse the transfer of electrons from a substrate to molecular oxygen. Superoxide radicals and hydrogen peroxide (H202) are the immediate products of such reactions and can be destroyed by enzymes such as superoxide dismutase (SOD) and catalase. However, under certain circumstances, the reactive oxygen species can interact to form highly reactive hydroxyl radicals (3).
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Anderson, D., Phillips, B.J. (1991). Toxic Effects of Oxygen and Antioxidants in Cho Cells and Rat Embryos in Culture. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_48
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_48
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