Abstract
WR-2721 and its free thiol WR-1065 have been found to effectively protect against radiation- and/or chemotherapy-induced mutagenesis (1-4), transformation (3) and carcinogenesis (6,7). With respect to the antimutagenic effect, WR-1065 significantly reduced the frequency of HGPRT mutants even when it was administered up to three hours following exposure of cells to radiation (1,4).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.J. Grdina, B. Nagy, C.K. Hill, R.L. Wells, and C. Peraino, The radioprotector WR-1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis, 6, 929–939 (1985).
B. Nagy, P.J. Dale, and D.J. Grdina, Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino] ethanethiol. Cancer Res., 46, 1132–1135 (1986).
B. Nagy, and D.J. Grdina, Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells. Int. J. Radiat. Oncol. Biol. Phys., 12, 1475–1478 (1986).
D.J. Grdina, C.P. Sigdestad, and B.A. Carnes, Protection by WR-1065 and WR-151326 against fission-neutron induced mutations at the HGPRT locus in V79 cells. Radiat. Res., 117, 500–510 (1989).
C.K. Hill, B. Nagy, C. Peraino, and D.J. Grdina, 2-[(aminopropyl)amino] ethanethiol (WR-1065) is anti-neoplastic and anti-mutagenic when given during 60Co 7-ray irradiation. Carcinogenesis, 7, 665–668 (1986).
D.J. Grdina, C. Peraino, B.A. Carnes, and C.K. Hill, Protective effect of S-2-(3-aminopropylamino) ethyl phosphorothioic acid against induction of altered hepatocyte foci in rats tested once with 7-radiation within one day after birth. Cancer Res., 45, 5379–5381 (1985).
L. Milas, N. Hunter, C.L. Stephens, and L.J. Peters, Inhibition of radiation carcinogenesis by S-2-(3-aminopropylamino) ethyl phosphorothioic acid. Cancer Res., 44, 5567–5569 (1984).
I. Johansen and P. Howard-Flanders, Macromolecular repair and free radical scavenging in the protection of bacteria against X-rays. Radiat. Res., 24, 184–200 (1965).
G.E. Adams, G.S. McNaughton, and B.D. Michael, Pulse radiolysis of sulphur compounds. Part 2. Free radical repair by hydrogen transfer from sulphydryl compounds. Trans. Faraday Soc., 64, 902–910 (1968).
R.E. Durand, Radioprotection by WR-2721 in vitro at low oxygen tensions: Implications for its mechanisms of action. Br. J Cancer, 47, 387–392 (1983).
S.E. Bresler, L.A. Noskin, I.M. Stepanova, and N.A. Kuzovleva, Mechanism of the radioprotecting action of chemical compounds on Escherichia coli cells. Mol. Gen. Genet., 163, 75–85 (1978).
J.W. Hulsewede and D. Schulte-Frohlinde, Radiation protection of E. coli strains by cysteamine in the presence of oxygen. Int. J. Radiat. Biol., 50, 861–869 (1986).
V.G. Petin and V.L. Matrenina, Radioprotecting action of chemical compounds on 7-irradiated yeast cells of various genotypes. Mol. Gen. Genet., 183, 152–157 (1981).
L.H. Thompson, K.W. Brookman, L.E. Dillehay, A.V. Carrano, J.A. Mazrimas, C.L. Mooney, and J.L. Minkler, A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange. Mutat. Res., 95, 427–440 (1982).
P.A. Jeggo and L.M. Kemp, X-ray sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents. Mutat. Res., 112, 313–327 (1983).
L.M. Kemp, S.G. Sedgwick, and P.A. Jeggo, X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining. Mutat. Res., 132, 189–196 (1984).
R.C. Fahey, Protection by thiols. Pharmacol. Ther., 39, 101–108 (1988)
P.E. Brown, Mechanism of action of aminothiol radio-protectors. Nature, 213, 363–364 (1967).
J.L. Schwartz, S.M. Giovanazzi, T. Karrison, C. Jones, and D.J. Grdina, 2-[(aminopropyl)amino] ethanethiol-mediated reduction in 60Co 7-ray and fission spectrum neutron induced chromosome damage in V79 cells. Radiat.Res., 113, 145–154 (1988).
M. LaSalle and D. Billen, Inhibition of DNA synthesis in murine bone-marrow cells by AET and cysteamine. Ann. New York Acad. Sci., 114, 622–628 (1964).
D.J. Grdina and B. Nagy, The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation-induced DNA damage and repair and cell progression in V79 cells. Br. J Cancer, 54, 933–941 (1986).
D.J. Grdina, C.P. Sigdestad, P.J. Dale, and J.M. Perrin, The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair. Br. J Cancer, 59, 17–21 (1989).
A. Chatterjee, and M. Jacob-Raman, Modifying effect of reduced glutathione on X-ray-induced chromosome aberration and cell-cycle delay in mutagenic lymphocytes in vitro. Mutat. Res., 175, 73–82 (1986).
C.P. Sigdestad, W. Guilford, J. Perrin, and D.J. Grdina, Cell cycle redistribution of cultured cells after treatment with chemical radiation protectors. Cell Tissue Kinet., 21, 193–200 (1988).
E. Riklis, R. Kol, M. Green, A. Prager, R. Marko, and M. Mintsberg, Increased radioprotection attained by DNA repair enhancement. Pharmacol. Ther., 39, 311–322 (1988).
J.F. Ward, Biochemistry of DNA lesions. Radiat. Res., 104, S–103–5–111 (1985).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Grdina, D.J., Nagy, B., Meechan, P.J. (1991). Effect of an Aminothiol (WR-1065) on Radiation-Induced Mutagenesis and Cytotoxicity in Two Repair-Deficient Mammalian Cell Lines. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_41
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3850-9_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6718-5
Online ISBN: 978-1-4615-3850-9
eBook Packages: Springer Book Archive