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Protection of Nuclear Enzymes by Aminothiols

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Anticarcinogenesis and Radiation Protection 2

Abstract

The maintenance of an intact DNA repair capacity is a necessary requirement for cell physiology and for survival. On the other hand, long-lasting DNA lesions, induced by physical or chemical agents, represent the first step in aging (1), mutagenesis (2,3) or in the multistage carcinogenic process (4-6). Impaired DNA repair synthesis has been shown to be responsible for increased neoplastic development in human subjects affected by repairdeficient syndromes such as: Xeroderma pigmentosum, Ataxia telangiectasia, Bloom’s syndrome, Fanconi’s anemia (7,8).

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Author information

Authors and Affiliations

  1. Institute of General Physiology, University of Genoa, Genoa, I-16132, Italy

    C. F. Cesarone, L. Scarabelli, P. Giannoni & M. Orunesu

  2. Institute of Hygiene and Preventive Medicine, University of Genoa, Genoa, I-16132, Italy

    R. Izzo & A. Izzotti

  3. Institute of Biological Chemistry, University of Verona, Verona, I-37134, Italy

    M. Menegazzi & H. Suzuki

  4. Institute of Biochemical and Evolutionary Genetics, National Research Council (CNR), Pavia, I-27100, Italy

    A. I. Scovassi & U. Bertazzoni

Authors
  1. C. F. Cesarone
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  2. M. Menegazzi
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  3. L. Scarabelli
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  4. A. I. Scovassi
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  5. P. Giannoni
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  6. R. Izzo
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  7. H. Suzuki
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  8. A. Izzotti
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  9. M. Orunesu
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  10. U. Bertazzoni
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Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Oddvar F. Nygaard

  2. New York University Medical Center, New York, USA

    Arthur C. Upton

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© 1991 Springer Science+Business Media New York

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Cesarone, C.F. et al. (1991). Protection of Nuclear Enzymes by Aminothiols. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_38

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  • DOI: https://doi.org/10.1007/978-1-4615-3850-9_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6718-5

  • Online ISBN: 978-1-4615-3850-9

  • eBook Packages: Springer Book Archive

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