Abstract
It is widely accepted and experimentally confirmed that thiyl radicals are formed as intermediate species in biological systems by several different processes (1-3). Thiyl radicals have long been considered unreactive and harmless. Their fate has commonly been ascribed to the dimerization reaction, i.e. the formation of disulfide molecules. However, generally this reaction is not very likely to occur in biological systems, as pointed out by Wardman (3). This is due to the low steady-state concentration of thiyl radicals. Furthermore, there is accumulating experimental evidence that thiyl radicals are also highly reactive toward molecular species. The redox properties of thiyl radicals, their pronounced tendency to stabilize by forming three-electron bonded complexes and the mechanism of addition to oxygen have recently been reviewed (1,3-6). Only the H-atom abstraction reaction by thiyl radicals, recently recognized to have pronounced biological significance, will be discussed here.
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Bonifačić, M. (1991). H-Atom Abstraction by Thiyl Radicals. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_34
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_34
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