Skip to main content
SpringerLink
Log in

Biological Monitoring of Exposure to Polycyclic Aromatic Hydrocarbons

  • Chapter
Anticarcinogenesis and Radiation Protection 2

  • 112 Accesses

Abstract

Methods are now available for the sensitive detection and quantitation of carcinogen-DNA adducts which do not depend upon radiolabeled carcinogens. These methods are essential for the measurement of adducts in humans with exposure to environmental and occupational carcinogens. Measurement of carcinogen-DNA adducts in the target tissue, termed biologically effective dose, is believed to be a more relevant marker of exposure than measurement of the chemical itself either in the environment or in body fluids (1). Such assays take into account individual differences in absorption and metabolism of carcinogens as well as repair of adducts. Since target tissue (e.g., lung, liver) is not available on a routine basis from healthy individuals, white blood cells have been utilized in a number of biomonitoring studies as a surrogate source of DNA.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. F.P. Perera and I.B. Weinstein, Molecular epidemiology and carcinogen-DNA adduct detection: New approaches to studies of human cancer causation. J.Chron. Dis. 35, 581–600 (1982).

    Article  PubMed  CAS  Google Scholar 

  2. M.C. Poirier, The use of carcinogen-DNA adduct antisera for quantitation and localization of genomic damage in animal models and the human population. Environ Mutag. 6, 879–887 (1984).

    Article  CAS  Google Scholar 

  3. R.M. Santella, Application of new techniques for the detection of carcinogen adducts to human population monitoring. Mutat. Res. 205, 271–282 (1988).

    Article  PubMed  CAS  Google Scholar 

  4. E. Hebert, G. Saint-Ruf, and M. Leng, Immunological titration of 3-N-acetyl-hydroxyamino-4,6-dimethyldipyrido(1,2-a:3’,2’-d)imidazolerat liver DNA adducts. Carcinogenesis 6, 937–939 (1985).

    Article  PubMed  CAS  Google Scholar 

  5. E. Sage, R.P. Fuchs, and M. Leng, Reactivity of the antibodies to DNA modified by the carcinogen N-acetoxy-N-acetyl-2-aminofluorene. Biochemistry 18, 1328–1334 (1979).

    Article  PubMed  CAS  Google Scholar 

  6. M. Leng, E. Sage, R.P.P. Fuchs, and M.P. Daune, Antibodies to DNA modified by the carcinogen N-acetoxy-N-2-acetylaminofluorene. FEES Lett. 92, p. 207 (1978).

    Article  CAS  Google Scholar 

  7. S.S. Ball, V. Quaranta, F. Shadravan, and R.L. Walford, An ELISA for detection of DNA-bound carcinogen using a monoclonal antibody to N-acetoxy-2-acetylaminofluorene-modified DNA. J. Immunol. Methods 98, 195–200 (1987).

    Article  PubMed  CAS  Google Scholar 

  8. M.C. Poirier, S.H. Yuspa, I.B. Weinstein, and S. Blobstein, Detection of carcinogen-DNA adducts by radioimmunoassay. Nature (London) 270, 186–188 (1977).

    Article  CAS  Google Scholar 

  9. M. Guigues and M. Leng, Reactivity of Antibodies to Guanosine Modified by the Carcinogen N-acetoxy-N-2-acetylaminofluorene. Nucleic Acids Res. 6, 733–744 (1979).

    Article  PubMed  CAS  Google Scholar 

  10. C.J. Van der Laken, A.M. Hagenaars, G. Hermsen, E. Kriek, A.J. Kuipers, J. Nagel, E. Scherer, and M. Welling, Measurement of 06-ethyldeoxyguanosine and N-(deoxyguanosine-8-yl)-N-acetyl-2aminofluorene in DNA by high-sensitive enzyme immunoassays. Carcinogenesis 3, 569–572 (1982).

    Article  PubMed  Google Scholar 

  11. R.A. Baan, M.J. Lansbergen, P.A.F. Bruin, M.I. Willems, and P.H.M. Lohman, The organ-specific induction of DNA adducts in 2-acetylaminofluorenetreated rats, studied by means of a sensitive immunochemical method. Mutat. Res 150, 23–32 (1985).

    Article  PubMed  CAS  Google Scholar 

  12. A. Haugen, J.D. Groopman, I.C. Hau, G.R. Goodrich, G.W. Wogan, and C.C. Harris, Monoclonal antibody to aflatoxin B1-modified DNA detected by enzyme immunoassay. Proc. Natl. Acad. Sci. USA 78, 4124–4127 (1981).

    Article  PubMed  CAS  Google Scholar 

  13. P.J. Hertzog, J.R.L. Smith, and R.C. Garner, Production of monoclonal antibodies to guanine imidazole ring opened aflatoxin B1 DNA, the persistent DNA adduct in vivo. Carcinogenesis 3, 825–828 (1982).

    Article  PubMed  CAS  Google Scholar 

  14. D.W. Roberts, R.W. Benson, J.D. Groopman, T.J. Flammang, W.A. Nagle, A.J. Moss, and F.F. Kadlubar, Immunochemical quantitation of DNA adducts derived from the human bladder carcinogen, 4-aminobiphenyl. Cancer Res. 48, 6336–6342 (1988).

    PubMed  CAS  Google Scholar 

  15. M.C. Poirier, J. Nakayama, F.P. Perera, I.B. Weinstein, and S.H. Yuspa, Identification of carcinogen-DNA adducts by immunoassays. In: “Application of Biological Markers to Carcinogen Testing” (H.A. Milman and S. Sell, Eds.), pp. 427–440. Plenum, New York, 1983.

    Chapter  Google Scholar 

  16. P. Rio and M. Leng, Antibodies to N-(guanosine-8-y1)-2-aminofluorene. Biochimie 62, 487–490 (1980).

    Article  PubMed  CAS  Google Scholar 

  17. L.L. Hsieh, A.M. Jeffrey, and R.M. Santella, Monoclonal antibodies to 1-aminopyrene-DNA. Carcinogenesis 6, 1289–1293 (1985).

    Article  PubMed  CAS  Google Scholar 

  18. M.C. Poirier, R. Santella, I.B. Weinstein, D. Grunberger, and S.H. Yuspa, Quantitation of benzo[a]pyrene-deoxyguanosine adducts by radioimmunoassay. Cancer Res. 40, 412–416 (1980).

    PubMed  CAS  Google Scholar 

  19. R.M. Santella, C.D. Lin, W.L. Cleveland, and I.B. Weinstein, Monoclonal antibodies to DNA modified by a benzo[a]pyrene diol epoxide. Carcinogenesis 5, 373–377 (1984).

    Article  PubMed  CAS  Google Scholar 

  20. H. Slor, N. Mizusawa, T. Nechart, R. Kakefuda, R.S. Day, and M. Bustin, Immunochemical visualization of binding of the chemical carcinogen benzo[a]pyrene diol epoxide to the genome. Cancer Res. 41, 3111–3117 (1981).

    PubMed  CAS  Google Scholar 

  21. F.J. van Schooten, E. Kriek, M.S.T. Steenwinkel, H.P.J.M. Noteborn, M.J.X. Hillebrand, and F.E. vanLeeuwen, The binding efficiency of polyclonal and monoclonal antibodies to DNA modified with benzo[a]pyrene diol epoxide is dependent on the level of modification. Implications for quantitation of benzo[a]pyrene-DNA adducts in vivo. Carcinogenesis 8, 1263–1269 (1987).

    Article  PubMed  Google Scholar 

  22. R. Muller and M.F. Rajewsky, Antibodies specific for DNA components structurally modified by chemical carcinogens. J. Cancer Res. Clin. Oncol. 102, 99–113 (1981).

    Article  PubMed  CAS  Google Scholar 

  23. B. Malfoy, B. Hartmann, J.P. Macquet, and M. Leng, Immunochemical studies of DNA modified by cis-dichlorodiaamine platinum (II). Cancer Res. 41, 4127–4131 (1981).

    PubMed  CAS  Google Scholar 

  24. M.C. Poirier, S. Lippard, L.A. Zwelling, M. Ushay, D. Kerrigan, R.M. Santella, D. Grunberger, and S.H. Yuspa, Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro. Proc. Natl. Acad. Sci. USA 79, 6443–6447 (1982).

    Article  PubMed  CAS  Google Scholar 

  25. A. Fichtinger-Schepman, R. Baan, A. Luiten-Schuite, M. VanDijk, and P.H.M. Lohman, Immunochemical quantitation of adducts induced in DNA by cis-diamminedichloroplatinum(II) and analysis of adduct related DNA-unwinding. Chem-Biol. Interact. 55, 275–288 (1985).

    Article  PubMed  CAS  Google Scholar 

  26. R. Mustonen, K. Hemminki, A. Alhonen, P. Hietanen, and M. Kiilunen, Determination of cis-diamminedichlorodiplatinum (II) in blood compartments of cancer patients. In: “Detection Methods for DNA-Damaging Agents in Humans an: Applications in Cancer Epidemiology and Prevention” (K. Hemminki and H. Bartsch, Eds.). IARC, Lyon, 1988.

    Google Scholar 

  27. W.I. Sundquist, S.J. Lippard and B.D. Stollar, Monoclonal antibodies to DNA modified with cis-or trans-diamminedichloroplatinum (II). Proc. Natl. Acad. Sci. USA 84, 8225–8229 (1987).

    Article  PubMed  CAS  Google Scholar 

  28. P.G. Foiles, F.L. Chung, and S.S. Hecht, Development of a monoclonal antibody based immunoassay for cyclic DNA adducts resulting from exposure to crotonaldehyde. Cancer Res. 47, 360–363 (1986).

    Google Scholar 

  29. T.L. Young and R.M. Santella, Development of techniques to monitor for exposure to vinyl chloride: monoclonal antibodies to ethenoadenosine and ethenocytine. Carcinogenesis 9, 589–592 (1988).

    Article  PubMed  CAS  Google Scholar 

  30. G. Eberle, A. Barbin, R.J. Laib, F. Ciroussel, J. Thomale, H. Bartsch, and M.F. Rajewsky, 1,N6-etheno-2’-deoxyadenosine and 3,N4-etheno2’deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride. Carcinogenesis 10, 209–212 (1989).

    Article  PubMed  CAS  Google Scholar 

  31. R. Muller and M.F. Rajewsky, Immunological quantification by high-affinity antibodies of 06-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea. Cancer Res. 40, 887–896 (1980).

    PubMed  CAS  Google Scholar 

  32. M.F. Rajewsky, R. Muller, J. Adamkiewicz, and W. Drosdziok, Immunological detection and quantification of DNA components structurally modified by alkylating carcinogens. In: “Carcinogenesis: Fundamental Mechanisms and Environmental Effects” (B. Pullman, P.O.P. Tso and H. Gelboin, Eds.), pp. 207–218. Reidel Publ. Co., Dordrecht and Boston, 1980.

    Chapter  Google Scholar 

  33. M.J. Tilby, J.M. Styleg, and C.J. Dean, Immunological Detection of DNA Damage Caused by Melphalan Using Monoclonal Antibodies. Cancer Res. 47, 1542–1546 (1987).

    PubMed  CAS  Google Scholar 

  34. R.M. Santella, N. Dharmaraja, F.P. Gasparro, and R.L. Edelson, Monoclonal antibodies to DNA modified by 8-methoxypsoralen and ultraviolet A light. Nucleic Acids Res, 13, 2533–2544 (1985).

    Article  PubMed  CAS  Google Scholar 

  35. Z. Zarebska, M. Jarbabek-Chorzelska, T. Chorzelski, and S. Zablonska, Immune serum against anti DNA-8-methoxypsoralen photoadduct. Z. Naturforsch 39, 136–140 (1984).

    CAS  Google Scholar 

  36. C.P. Wild, G. Smart, R. Saffhill and J.M. Boyle, Radioimmunoassay of 06methyldeoxyguanosine in DNA of cells alkylated in vitro and in vivo. Carcinogenesis 4, 1605–1609 (1983).

    Article  PubMed  CAS  Google Scholar 

  37. T.W. Munns, M.K. Liszewski, H.F. Sims, et al, Characterization of antibodies specific for N6-methyladenosine and for 7-methylguanosine. Biochemistry 16, 2163–2168 (1977).

    Article  PubMed  CAS  Google Scholar 

  38. R.D. Meridith and B.F. Erlanger, Isolation and characterization of rabbit anti-m7G-5’-P antibodies of high apparent affinity. Nucleic Acids Res. 6, 2179–2191 (1979).

    Article  Google Scholar 

  39. P. Degan, R. Montesano, and C.P. Wild, Antibodies against 7-methyldeoxyguanosine: Its detection in rat peripheral blood lymphocyte DNA and potential applications to molecular epidemiology. Cancer Res. 48, 5065–5070 (1988).

    PubMed  CAS  Google Scholar 

  40. A.M. Stein, H.G. Gratzner, J.H. Stein, and M.M. McCabe, High avidity monoclonal antibody to imidazole ring-opened ethylguanine. Carcinogenesis 10, 927–973 (1989).

    Article  PubMed  CAS  Google Scholar 

  41. P.T. Strickland and J.M. Boyle Immunoassay of carcinogen-modified DNA. In: “Progress in Nucleic Acid Research & Molecular Biology” (W.E. Cohn Ed.), pp. 1–58. Academic Press, New York, 1984.

    Google Scholar 

  42. T. Morita, S. Ikeda, Y. Minoura, M. Kojima and M. Tada, Polyclonal antibodies to DNA modified with 4-nitroquinoline 1-oxide application for the detection of 4-nitroquinoline 1-oxide-DNA adducts in vivo. J. Cancer Res,79, 195–203 (1988).

    CAS  Google Scholar 

  43. G. Miolo, M. Stefanidis, R.M. Santella, F. Acqua, and F. Gasparro, 6,4,4’-Trimethylangelecin photoadduct formation in DNA: production and characterization of a specific monoclonal antibody. Photochem. Photobiol. 3, 101–112 (1989).

    Article  CAS  Google Scholar 

  44. P.T. Strickland and J.M. Boyle, Characterisation of two monoclonal antibodies specific for dimerised and non-dimerised adjacent thymidines in single stranded DNA. Photochem. Photobiol. 34, 595–601 (1981).

    PubMed  CAS  Google Scholar 

  45. A.A. Wani, R.E. Gibson-D’Ambrosio, and M.D. D’Ambrosio, Antibodies to UV Irradiated DNA: the monitoring of DNA damage by ELISA and indirect immunofluorescence. Photochem. Photobiol, 40, 465–471 (1984).

    Article  PubMed  CAS  Google Scholar 

  46. R.D. Ley, Immunological detection of two types of cyclobutane pyrimidine dimers in DNA. Cancer Res, 43, 41–45 (1983).

    PubMed  CAS  Google Scholar 

  47. S.A. Leadon and P.C. Hanawalt, Monoclonal antibody to DNA containing thymine glycol. Mutat. Res. 112, 191–200 (1983).

    Article  PubMed  CAS  Google Scholar 

  48. D. Randerath, M.V. Reddy, and R.A.C. Gupta, [32P]-labeling test for DNA damage. Proc. Natl. Acad. Sci. USA 78, 6126–6129 (1981).

    Article  PubMed  CAS  Google Scholar 

  49. M.V. Reddy, R.C. Gupta, E. Randerath, and K. Randerath, 32P-Postlabeling test for covalent DNA binding of chemicals in vivo: application to a variety of aromatic carcinogens and methylating agents. Carcinogenesis 5, 231–243 (1984).

    Article  PubMed  Google Scholar 

  50. V.L. Wilson, A.K. Basu, J.M. Essigmann, R.A. Smith, and C.C. Harris, 06-Alkyldeoxyguanosine detection by 32P-postlabeling and nucleotide chromatographic analysis. Cancer Res. 48, 2156–2161 (1988).

    PubMed  CAS  Google Scholar 

  51. R.C. Gupta and K. Earley, 32P-adduct assay: comparative recoveries of structurally diverse DNA adducts in the various enhancement procedures. Carcinogenesis 9, 1687–1693 (1988).

    Article  PubMed  CAS  Google Scholar 

  52. M.V. Reddy and K. Randerath, Nuclease P1-mediated enhancement of sensitivity of [32P]-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7, 1543–1551 (1986).

    Article  PubMed  CAS  Google Scholar 

  53. C.C. Harris, K. Vahakangas, J.M. Newman, G.E. Trivers, A. Shamsuddin, N. Sinopoli, D.L. Mann, and W.E. Wright, Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc. Natl. Acad. Sci. USA 82, 6672–6676 (1985).

    Article  PubMed  CAS  Google Scholar 

  54. A. Weston, M.I. Rowe, D.K. Manchester, P.B. Farmer, D.L. Mann, and C.C. Harris, Fluorescence and mass spectral evidence for the formation of benzo(a)pyrene anti-diol-epoxide-DNA and -hemoglobin adducts in humans. Carcinogenesis 10, 251–257 (1989).

    Article  PubMed  CAS  Google Scholar 

  55. A.M. Jeffrey, I.B. Weinstein, K.W. Jennette, K. Grzeskowiak, K. Nakanishi, R.G. Harvey, H. Autrup, and C. Harris, Structures of benzo[a]pyrene-nucleic acid adducts formed in human and bovine bronchial explants. Nature (London) 269, 348–350 (1977).

    Article  CAS  Google Scholar 

  56. R.M. Santella, F.P. Gasparo, and L.L. Hsieh, Quantitation of carcinogen-DNA adducts with monoclonal antibodies. Prog. in Exp. Tumor Res. 31, 63–75 (1987).

    CAS  Google Scholar 

  57. R.M. Santella, A. Weston, F.P. Perera, G.T. Trivers, C.C. Harris, T.L. Young, D. Nguyen, B.M. Lee and M.C. Poirier, Interlaboratory comparison of antisera and immunoassays for benzo(a)pyrene-diolepoxide-I-modified DNA. Carcinogenesis 9, 1265–1269 (1988).

    Article  PubMed  CAS  Google Scholar 

  58. X.Y. Yang, V. DeLeo, and R.M. Santella, Immunological detection and visualization of 8-methoxypsoralen-DNA photoadducts. Cancer Res. 47, 2451–2455 (1987).

    PubMed  CAS  Google Scholar 

  59. F.P. Perera, K. Hemminki, T.L. Young, R.M. Santella, D. Brenner, and G. Kelly, Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Cancer Res. 48, 2288–2291 (1988).

    PubMed  CAS  Google Scholar 

  60. D.H. Phillips, K. Hemminki, A. Alhonen, A. Hewer, and P.L. Grover, Monitoring occupational exposure to carcinogens: detection by 32P-Postlabeling of aromatic DNA adducts in white blood cells from iron foundry workers. Mutat. Res. 204, 531–541 (1988).

    Article  PubMed  CAS  Google Scholar 

  61. K. Hemminki, E. Grzybowska, M. Chorazy, K. Twardowska-Saucha, J.W. Sroczynski, K.L. Putnam, K. Randerath, D.A. Phillips, H. Hewer, R.M. Santella, T.L. Young, and F.P. Perera, DNA adducts in humans environmentally exposed to aromatic compounds in an industrial area of Poland. Carcinogenesis 11, 1229–1231 (1990).

    Article  PubMed  CAS  Google Scholar 

  62. R.B. Everson, E. Randerath, R.M. Santella, R.C. Cefalo, T.A. Avitts, and K. Randerath, Detection of smoking-related covalent DNA adducts in human placenta. Science 231, 54–57 (1986).

    Article  PubMed  CAS  Google Scholar 

  63. R.B. Everson, E. Randerath, R.M. Santella, T.A. Avitts, I.B. Weinstein, and K. Randerath, Quantitative associations between DNA damage in human placenta and maternal smoking and birth weight. J. Natl. Cancer Inst. 80, 567–576 (1988).

    Article  PubMed  CAS  Google Scholar 

  64. F. Perera, J. Mayer, A. Jaretzki, S. Hearne, D. Brenner, T.L. Young, K. Fischman, M.X. Grimes, S. Grantham, Tang, W.Y. Tsai and R.M. Santella, Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Cancer Res. 49, 4446–4451 (1989).

    PubMed  CAS  Google Scholar 

  65. B. Paigen, E. Ward, A. Reilly, L. Houten, H.L. Gurtoo, K. Minowada, J. Steenland, M.B. Havens, and P. Satori, Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes. Cancer Res. 41, 2757–2761 (1981).

    PubMed  CAS  Google Scholar 

  66. L. Shugart, Quantifying adductive modification of hemoglobin from mice exposed to benzo[a]pyrene. Anal. Biochem. 152, 365–369 (1986).

    Article  PubMed  CAS  Google Scholar 

  67. H. Wallin, A.M. Jeffrey, and R.M. Santella, Investigation of benzo[a]pyrene-globin adducts. Cancer Lett. 35, 139–146 (1987).

    Article  PubMed  CAS  Google Scholar 

  68. B.M. Lee and R.M. Santella, Quantitation of protein adducts as a marker of genotoxic exposure: immunologic detection of benzo(a)pyrene-globin adducts in mice. Carcinogenesis 9, 1773–1777 (1988).

    Article  PubMed  CAS  Google Scholar 

  69. A. Weston, G. Trivers, J.K. Vahakangas, M. Newman, and M. Rowe, Detection of carcinogen-DNA adducts in human cells and antibodies to these adducts in human sera. Prog. Exp. Tumor Res. 31, 76–85 (1987).

    PubMed  CAS  Google Scholar 

  70. IARC monographs on the evaluation of the carcinogenic risks of chemicals to humans: polynuclear aromatic compounds, IARC, Lyon (1984).

    Google Scholar 

  71. D.R. Bickers, The carcinogenicity and mutagenicity of therapeutic coal tar--A perspective. J. Invest. Dermatol 77, 173–174 (1981).

    Article  PubMed  CAS  Google Scholar 

  72. A.R. Pittelkow, H.O. Perry, S.A. Muller, W.Z. Maughan, and P.C. O’Brien, Skin cancer in patients with psoriasis treated with coal tar. Arch. Dermatol. 117, 465–468 (1981).

    Article  PubMed  CAS  Google Scholar 

  73. R.S. Stern, S. Zierler, and J.A. Parrish, Skin carcinoma in patients with psoriasis treated with topical tar and artificial ultraviolet radiation. Lancet 2, 732–733 (1980).

    Article  Google Scholar 

  74. R.S. Stern, J. Scotto, and T.R. Fears, Psoriasis and susceptibility to non-melanoma skin cancer. J. Am. Acad. Dermatol. 12, 67–73 (1985).

    Article  PubMed  CAS  Google Scholar 

  75. J.S. Storer, I. DeLeon, L.E. Millikan, J.L. Laseter, and C. Griffing, Human absorption of crude coal tar products. Arch. Dermatol. 120, 874–877 (1984).

    Article  PubMed  CAS  Google Scholar 

  76. F.J. Jongeneelen, R.B.M. Anzion, C.M. Leijdekkers, R.P. Bos, and P.T. Henderson, 1-Hydroxypyrene in human urine after exposure to coal tar and a coal tar derived product. Int. Arch. Occup, Environ. Health 57, 47–55 (1985).

    Article  CAS  Google Scholar 

  77. E. Clonfero, M. Zordan, D. Cottica, P. Venier, L. Pozzoli E.L. Cardin, F. Sarto, and A.G. Levis, Mutagenic activity and polycyclic aromatic hydrocarbon levels in urine of humans exposed to therapeutical coal tar. Carcinogenesis 7, 819–823 (1986).

    Article  PubMed  CAS  Google Scholar 

  78. E. Clonfero, M. Zordan, P. Venier, M. Paleologo, A.G. Levis, L. Cottica, D. Pozzoli, F.J. Jongeneelen, R.P. Bos and R.B.M. Ansion, Biological monitoring of human exposure to coal tar locus in Chinese hamster ovary cells. Int. Arch. Occup. Environ. Health 61, 363–368 (1989).

    Article  PubMed  CAS  Google Scholar 

  79. L.A. Wheeler, M.D. Saperstein, and N.J. Lowe, Mutagenicity of urine from psoriatic patients undergoing treatment with coal tar and ultraviolet light. J. Invest. Dermatol. 77, 181–185 (1981).

    Article  PubMed  CAS  Google Scholar 

  80. F. Sato, M. Zordan, R. Tomanin, D. Mazzotti, A. Canova, E.L. Cardin, G. Bezze, and A.G. Levis, Chromosomal alterations in peripheral blood lymphocytes, urinary mutagenicity and excretion of polycyclic aromatic hydrocarbons in six psoriatic patients undergoing coal tar therapy. Carcinogenesis 10, 329–334 (1989).

    Article  Google Scholar 

  81. M.C. Poirier, J.R. Stanley, J.B. Beckwith, I.B. Weinstein, and S.H. Yuspa, Indirect immunofluorescent localization of benzo[a]pyrene adducted to nucleic acids in cultured mouse keratinocyte nuclei. Carcinogenesis 3, 345–348 (1982).

    Article  PubMed  CAS  Google Scholar 

  82. S.A. Lesko, D.E. Callahan, D.S. Kaplan, W. Li, W.R. Midden, P.T. Strickland, and G. Zheng, Quantitative immunofluorescence assay for cyclobutyldithimidine dimers in individual mammalian cells. Carcinogenesis 10, 641–646 (1989).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Comprehensive Cancer Center and Division of Environmental Sciences, School of Public Health, Columbia University, New York, NY, 10032, USA

    Regina M. Santella, Yu Jing Zhang, Tie Lan Young, You Lil, Byung Mu Leel, Marina Stefanidis & Frederica P. Perera

  2. Department of Human Genetics, Columbia University, New York, NY, 10032, USA

    Mohammed Toor & Dorothy Warburton

  3. Department of Dermatology, Columbia University, New York, NY, 10032, USA

    Vincent DeLeo

Authors
  1. Regina M. Santella
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu Jing Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tie Lan Young
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. You Lil
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mohammed Toor
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Byung Mu Leel
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Marina Stefanidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Dorothy Warburton
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Vincent DeLeo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Frederica P. Perera
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Oddvar F. Nygaard

  2. New York University Medical Center, New York, USA

    Arthur C. Upton

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Santella, R.M. et al. (1991). Biological Monitoring of Exposure to Polycyclic Aromatic Hydrocarbons. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3850-9_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6718-5

  • Online ISBN: 978-1-4615-3850-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation