Abstract
Genetic and molecular analyses of Drosophila have clearly demonstrated that tumorigenesis may arise from inactivation of genes controlling cell growth and differentiation (1,2). Recessive mutations in a series of genes were shown to interrupt the differentiation of certain primordial cells and result in uncontrolled and invasive cell proliferation. As a consequence, the mutant animals form malignant tumors in either the optic centers of the larval brain, the imaginal discs, or the hematopoietic organs. Simultaneous with the appearance and growth of the neoplasms, the development of the mutant animals become impaired, and these animals die as larvae or pseudopupae.
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Mechler, B. (1991). Molecular Analysis of Tumorigenesis in Drosophila . In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_14
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_14
Publisher Name: Springer, Boston, MA
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