Abstract
Recent reports indicate that high-LET neutrons are significantly more toxic to biological systems than low-LET radiation (1). On a unit dose basis, neutrons are much more effective in transforming cultured cells than are X or gamma rays (2). Also, they are 2.7 times more effective in producing chromosomal aberrations (3) and 10 times more efficient in inducing mutations in mammalian cells than are gamma rays (4). In contrast, certain sources of neutrons are no more effective than gamma rays at producing double-strand DNA breaks (DSB) and are actually less effective at producing single strand DNA breaks (SSB) (5). For example, the relative biological effectiveness (RBE) for JANUS neutron-induced DSBs is 1, while the RBEs for chromosomal aberrations, mutations, cellular transformation, and carcinogenesis are in the range of 4 to 20.
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Nagy, B., Grdina, D.J., Ashman, C.R. (1991). Janus Neutron Irradiation of a Mouse Cell Line Containing a Shuttle Vector Plasmid. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_12
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_12
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