Abstract
Initial characterization of the sequential polypentapeptide, poly (VPAVG) an analog of the polypentapeptide of elastin poly (VPGVG), is reported. It undergoes a concentration dependent inverse temperature transition, in which it is soluble in water below 25°C and aggregates on raising the temperature. When crosslinked by 20 Mrads of γ-irradiation to give X20-poly (VPAVG), an elastomeric matrix is formed. At 25°C, this material exhibits an elastic modulus of 1.5 x 105 dynes/cm2, similar to that found at that temperature for X20-poly (VPGVG). On raising the temperature to 37°C, however, the elastic modulus increases three orders of magnitude to 3 × 108 dynes/cm2 which is two orders of magnitude greater than obtained for X20-poly (VPGVG). This reversible hardening on raising the temperature defines X20-poly (VPAVG) as a reversible, inverse thermoplastic. This property makes it an interesting new material to add to the already described set of bioelastic materials. The potential applications and extensions of applications made possible by this additional bioelastic material are briefly considered.
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Urry, D.W., Jaggard, J., Prasad, K.U., Parker, T., Harris, R.D. (1991). Poly (VAL1-PRO2-ALA3-VAL4-GLY5): A Reversible, Inverse Thermoplastic. In: Gebelein, C.G. (eds) Biotechnology and Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3844-8_21
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DOI: https://doi.org/10.1007/978-1-4615-3844-8_21
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