Abstract
Giardia lamblia is the major identified cause of waterborne enteric disease in the U.S. Nonetheless, knowledge of the biological interactions between G. lamblia and the host intestinal milieu is limited. We have proposed that the great variations in the clinical manifestations and duration of giardiasis are due to parasite interactions with both immune and non-immune components of this environments. Investigation of these interactions in vitro has begun to yield valuable information on aspects of parasite biology that may determine colonization and persistence of trophozoites in the human small intestine. As summarized below, we have demonstrated powerful non-immune giardiacidal activities of normal human milk (NHM)2 and duodenal fluid3 and have shown that Giardia can utilize certain other host intestinal secretions to survive, attach, multiply, and differentiate4–7.
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© 1991 Springer Science+Business Media New York
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Gillin, F.D., Cooper, R.W., Reiner, D.S., Das, S. (1991). Secretory Defenses Against Giardia Lamblia . In: Mestecky, J., Blair, C., Ogra, P.L. (eds) Immunology of Milk and the Neonate. Advances in Experimental Medicine and Biology, vol 310. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3838-7_30
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DOI: https://doi.org/10.1007/978-1-4615-3838-7_30
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