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Lactoferrin Binding to its Intestinal Receptor

  • Chapter
Immunology of Milk and the Neonate

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 310))

Abstract

Lactoferrin was first discovered in bovine milk in 19391. It was later found in high concentration in human milk2. Lactoferrin is a glycoprotein with a molecular weight of 78,000 and has the capacity to bind two ferric ions concomitant with bicarbonate or carbonate ions. The primary structure3 as well as the glycan structure4 have been documented and the tertiary structure has been elucidated by X-ray crystallography5. The protein consists of two lobes, each binding one iron atom and having one glycan; because of the similarity between the two lobes, the molecule is believed to be the result of an early gene duplication3. Lactoferrin is sometimes referred to as lactotransferrin3,4. However, even if lactoferrin and transferrin have some similar physicochemical properties, they are products of different genes and their biological functions are different.

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References

  1. M. Sorensen and S. P. L. Sorensen, C. R. Tray. Lab. Carlsberg Du 23: 55 (1939).

    CAS  Google Scholar 

  2. B. G. Johansson, Acta Chem. Scand. 14: 510 (1960).

    Article  Google Scholar 

  3. M. H. Metz-Boutigue, J. Jollés, J. Mazurier, F. Schoentgen, D. Legrand, G. Spik, J. Montreuil, and P. Jolies, Eur. J. Biochem. 145: 659 (1984).

    Article  PubMed  CAS  Google Scholar 

  4. G. Spik, G. Strecker, B. Fournet, S. Bouquelet, and J. Montreuil, Eur. J. Biochem. 121: 413 (1982).

    Article  PubMed  CAS  Google Scholar 

  5. B. F. Anderson, H. M. Baker, G. E. Norris, D. W. Rice, and E. N. Baker, Proc. Natl. Acad. Sci. USA 84: 1769 (1987).

    Article  PubMed  CAS  Google Scholar 

  6. P. L. Masson, J. F. Heremans, and C. Dive, Clin. Chim. Acta 14: 735 (1966).

    Article  CAS  Google Scholar 

  7. R. M. Bennett and C. Mohla, J. Lab. Clin. Med. 88: 156 (1976).

    PubMed  CAS  Google Scholar 

  8. P. L. Masson, J. F. Heremans, and E. Schonne, J. Exp. Med. 130: 643 (1969).

    Article  PubMed  CAS  Google Scholar 

  9. R. M. Bennett and T. Kokocinski, Brit. J. Haematol. 39: 509 (1978).

    Article  CAS  Google Scholar 

  10. R. Oria, X. Alvarez-Hernandez, J. Liceaga, and J. H. Brock, Biochem. J. 251: 221 (1988).

    Google Scholar 

  11. B. Lönnerdal, E. Forsum, M. Gebre-Medhin, and L. Hambraeus, Amer. J. Clin. Nutr. 29: 1134 (1976).

    PubMed  Google Scholar 

  12. G.-B. Fransson, K. N. Agarwal, M. Gebre-Medhin, and L. Hambraeus, Acta Paediatr. Scand. 74: 290 (1985).

    Article  PubMed  CAS  Google Scholar 

  13. M. R. Houghton, M. Gracey, V. Burke, C. Bottrell, and R. M. Spargo, J. Pediatr. Gastroenterol. Nutr. 4: 230 (1985).

    Article  PubMed  CAS  Google Scholar 

  14. J. J. Bullen, H. J. Rogers, and L. Leigh, Brit. J. Med. 1: 69 (1972).

    Article  CAS  Google Scholar 

  15. R. R. Arnold, M. F. Cole, and J. R. McGhee, Science 197: 263 (1977).

    Article  PubMed  CAS  Google Scholar 

  16. G.-B. Fransson and B. Lönnerdal, J. Pediatr. 96: 380 (1980).

    Article  PubMed  CAS  Google Scholar 

  17. B. J. C. M. deVet and J. van Gool, Acta Med. Scand. 196: 393 (1974).

    CAS  Google Scholar 

  18. B. Lönnerdal, in: “Iron Nutrition in Infancy and Childhood,” A. Stekel, ed., p. 95, Raven Press, New York (1984).

    Google Scholar 

  19. J. H. Brock, Arch. Dis. Child. 55: 417 (1980).

    Article  PubMed  CAS  Google Scholar 

  20. O. Koldovsky, J. Nutr. 119: 1543 (1989).

    PubMed  CAS  Google Scholar 

  21. B. L. Nichols, K. S. McKee, J. F. Henry, and M. Putman, Pediatr. Res. 21: 563 (1987).

    Article  PubMed  CAS  Google Scholar 

  22. H. Kawakami, S. Dosaki, and B. Lönnerdal, Amer. J. Physiol. 258: G535 (1990).

    PubMed  CAS  Google Scholar 

  23. W. F. Line, A. Sly, and A. Bezkorovainy, Internat. J. Biochem. 7: 203 (1976).

    Article  CAS  Google Scholar 

  24. J. H. Brock, F. Arzabe, F. Lampreave, and A. Pineiro, Biochim. Biophys. Acta 446: 214 (1976).

    Article  PubMed  CAS  Google Scholar 

  25. G. Spik, B. Brunet, C. Mazurier-Dehaine, G. Fontaine, and J. Montreuil, Acta Pediatr. Scand. 71: 979 (1982).

    Article  CAS  Google Scholar 

  26. L. A. Davidson and B. Lönnerdal, Acta Pediatr. Scand. 76: 740 (1987).

    Article  Google Scholar 

  27. T. W. Hutchens, J. F. Henry, and T.-T. Yip, Clin. Chem. 35: 1928 (1989).

    PubMed  CAS  Google Scholar 

  28. A. S. Goldman, C. Garza, R. J. Schanler, and R. M. Goldblum, Pediatr. Res. 27: 252 (1990).

    Article  PubMed  CAS  Google Scholar 

  29. R. M. Goldblum, R. J. Schanler, C. Garza, and A. J. Goldman, Pediatr. Res. 19: 342A (1985).

    Google Scholar 

  30. T. W. Hutchens, J. F. Henry, T.-T. Yip, D. Mackey, R. J. Schanler, K. J. Motil, and C. Garza, Pediatr. Res. 29: 243 (1990).

    Article  Google Scholar 

  31. T. M. Cox, J. Mazurier, G. Spik, J. Montreuil, and T. J. Peters, Biochim. Biophys. Acta 588: 120 (1979).

    Article  PubMed  CAS  Google Scholar 

  32. M. Baggiolini, C. DeDuve, P. L. Masson, and J. F. Heremans, J. Exp. Med. 131: 559 (1970).

    Article  PubMed  CAS  Google Scholar 

  33. H. S. Birgens, N. E. Hansen, H. Karle, and L. O. Kristensen, Brit. J. Haematol. 54: 383 (1983).

    Article  CAS  Google Scholar 

  34. H. S. Birgens, H. Karle, N. E. Hansen, and L. O. Kristensen, Scand. J. Haematol. 33: 275 (1984).

    Article  PubMed  CAS  Google Scholar 

  35. J. Mazurier, D. Legrand, W. L. Hu, J. Montreuil, and G. Spik, Eur. J. Biochem. 179: 481 (1989).

    Article  PubMed  CAS  Google Scholar 

  36. P. Masson and J. Heremans, Comp. Biochem. Physiol. 1339: 119 (1971).

    Google Scholar 

  37. L. A. Davidson and B. Lönnerdal, Pediatr. Res. 20: 197 (1986).

    Article  PubMed  CAS  Google Scholar 

  38. L. A. Davidson and B. Lönnerdal, Fed. Proc. 43: 468 (1984).

    Google Scholar 

  39. L. A. Davidson and B. Lönnerdal, Amer. J. Physiol. 254: G580 (1988).

    PubMed  CAS  Google Scholar 

  40. M. A. Huebers, and C. A. Finch, Physiol. Rev. 67: 520 (1987).

    PubMed  CAS  Google Scholar 

  41. H. Kawakami and B. Lönnerdal, FASEB J. 4: A1052 (1990).

    Google Scholar 

  42. L. A. Davidson and B. Lönnerdal, Amer. J. Physiol. 257: G930 (1989).

    PubMed  CAS  Google Scholar 

  43. Y. Leclerq, G. Sawatzki, J.-M. Wieruszeski, J. Montreuil, and G. Spik, Biochem. J. 247: 571 (1987).

    Google Scholar 

  44. W.-L. Hu, J. Mazurier, J. Montreuil, and G. Spik, Biochem. J. 248: 435 (1988).

    Google Scholar 

  45. W. -L. Hu, J. Mazurier, J. Montreuil, and G. Spik, Biochemistry 29: 535 (1990).

    Article  PubMed  CAS  Google Scholar 

  46. J. Mazurier, D. Legrand, W.-L. Hu, J. Montreuil, and G. Spik, Fur. J. Biochem. 179: 481 (1989).

    CAS  Google Scholar 

  47. J. Mazurier, J. Montreuil, and G. Spik, Biochim. Biophys. Acta 821: 453 (1985).

    Article  PubMed  CAS  Google Scholar 

  48. H. Kawakami, M. Hiratsuka, and S. Dosako, Agric. Biol. Chem. 52: 903 (1988).

    Article  CAS  Google Scholar 

  49. G.-B. Fransson, K. Thoren-Tolling, B. Jones, L. Hambraeus, B. Lönnerdal, Nutr. Res. 3: 373 (1983).

    Article  CAS  Google Scholar 

  50. J. I. Elliot, B. Senft, G. Erhardt, and D. Fraser, J. Anim. Sci. 59: 1080 (1984).

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Nutrition, University of California, Davis, CA, USA

    Bo Lönnerdal

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  1. Bo Lönnerdal
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Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky

  2. National Institutes of Health, Bethesda, Maryland, USA

    Claudia Blair

  3. University of Texas, Galveston, Texas, USA

    Pearay L. Ogra

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© 1991 Springer Science+Business Media New York

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Lönnerdal, B. (1991). Lactoferrin Binding to its Intestinal Receptor. In: Mestecky, J., Blair, C., Ogra, P.L. (eds) Immunology of Milk and the Neonate. Advances in Experimental Medicine and Biology, vol 310. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3838-7_17

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  • DOI: https://doi.org/10.1007/978-1-4615-3838-7_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6713-0

  • Online ISBN: 978-1-4615-3838-7

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