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Immunology of Milk and the Neonate pp 123–129Cite as

Immunological Properties and Differentiation Potential of Human Colostral Lymphocytes of B Cell Lineage

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 310))

Abstract

Human colostrum and milk contain approximately 1–5×106 cells/ml, identified by histochemical and immunohistochemical staining as macrophages (~40% of total cells), polymorphonuclear leukocytes (PMN), (~50%), lymphocytes (7–25%), and epithelial cells (~1%)1–4. Phenotypic analyses of lymphocytes revealed the presence of both B and T cells; the latter population is represented by CD4- and CD8-positive cells as well as γ/δ cells and NK cells2,5–7. Studies of colostral and milk lymphocytes of B cell lineage yielded controversial results with respect to their morphological properties, and their ability to respond in vitro to various stimuli and secrete immunoglobulins (Ig)1,2,4,8. The purpose of our studies was to re-evaluate the characteristics of colostral Ig-containing cells and to determine the transformability of B cells by the Epstein-Barr virus (EBV) which has been used in many studies of the differentiation potential of human B cells from various sources9.

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Author information

Authors and Affiliations

  1. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35295, USA

    Jiri Mestecky, Zina Moldoveanu, Shirley J. Prince, William H. Kutteh, Rose Kulhavy, Jerry R. McGhee & Sylvia S. Crago

  2. Department of Pathology, Nihon University School of Dentistry, Tokyo 101, Japan

    Itaru Moro

Authors
  1. Jiri Mestecky
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  2. Zina Moldoveanu
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  3. Shirley J. Prince
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  4. William H. Kutteh
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  5. Rose Kulhavy
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  6. Jerry R. McGhee
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  7. Itaru Moro
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  8. Sylvia S. Crago
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Editor information

Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky

  2. National Institutes of Health, Bethesda, Maryland, USA

    Claudia Blair

  3. University of Texas, Galveston, Texas, USA

    Pearay L. Ogra

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© 1991 Springer Science+Business Media New York

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Mestecky, J. et al. (1991). Immunological Properties and Differentiation Potential of Human Colostral Lymphocytes of B Cell Lineage. In: Mestecky, J., Blair, C., Ogra, P.L. (eds) Immunology of Milk and the Neonate. Advances in Experimental Medicine and Biology, vol 310. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3838-7_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3838-7_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6713-0

  • Online ISBN: 978-1-4615-3838-7

  • eBook Packages: Springer Book Archive

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