Skip to main content
SpringerLink
Log in

Effects of Triazenes on Immune Responses

  • Chapter
Triazenes

Abstract

One of the major goals of tumor immunology is the development of experimental procedures capable of enhancing responsiveness of the host to cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. N. Galili, B. Devens, D. Noor, S. Becker, and E. Klein, Immune responses to weakly immunogenic virally-induced tumors. I Overcoming low responsiveness by priming mice with syngeneic in vitro tumor line or allogeneic cross-reactive tumor, Eur. J. Immunol. 8:17 (1978).

    Article  PubMed  CAS  Google Scholar 

  2. J. Lindeman, and P. Klein, Viral Oncolysis: Increase on immunogenicity of host cell antigen associated with influenza virus, J. Exp. Med. 126:93 (1963).

    Article  Google Scholar 

  3. H. Kobayashi, T. Kodama, T. Shirai, H. Kaji, M. Hosokawa, F. Sendo, H. Saito, and N. Takeichi, Artificial regression of rat tumors injected with Friend virus (xenogenization): an effect produced by acguired antigen, Hokkaido J. Med. Sci. 44:133 (1969).

    Google Scholar 

  4. E. Benjamini, S. Fong, C. Erickson, C.Y. Leung, D. Rennick, R.J. Scibiensky, Immunity to lymphoid tumors induced in syngeneic mice by immunization with mitomycin C-treated cells, J. Immunol. 118:685 (1977).

    PubMed  CAS  Google Scholar 

  5. T. Boon, and O. Kellermann, Rejection by syngeneic mice of cell variants obtained by mutagenesis of a malignant teratocarcinoma cell line, Proc. Natl. Acad. Sci. USA 74:272 (1977).

    Article  PubMed  CAS  Google Scholar 

  6. T. Boon, Antigenic tumor cell variants obtained with mutagens, Adv. Cancer Res. 39:121 (1983).

    Article  PubMed  CAS  Google Scholar 

  7. G.J. Bekesi, J.F. Holland, J.P. Roboz, Immunotherapy trials with neuraminidase modified tumor cells, in: “Immunological approaches to cancer therapeutics”, E. Mihich ed., John Wiley, New York (1982).

    Google Scholar 

  8. E. Bonmassar, A. Bonmassar, S. Vadlamudi, and A. Goldin, Immunological alteration of leukemic cells in vivo after treatment with an antitumor drug, Proc. Nat. Acad. Sci. USA 66:1089 (1970).

    Article  PubMed  CAS  Google Scholar 

  9. E. Bonmassar, A. Bonmassar, S. Vladmudi, and A. Goldin, Antigenic changes of L1210 leukemia in mice treated with 5-(3,3’-Dimethyl-1-Triazeno)-Imidazole-4-Carboxamide, Cancer Res. 32:1446 (1972).

    PubMed  CAS  Google Scholar 

  10. A. Bonmassar, L. Frati, M.C. Fioretti, L. Romani, A. Giampietri, and A. Goldin, Changes of immunogenic properties of K36 lymphoma treated in vivo with 5-(3,3’-Dimethyl-1-Triazeno)-Imidazole-4-Carboxamide (DTIC), Eur. J. Cancer 15:933 (1979).

    Article  PubMed  CAS  Google Scholar 

  11. B. Nardelli, A. R. Contessa, L. Romani, G. Sava, C. Nisi, and M.C. Fioretti, Immunogenic changes of murine lymphoma cells following in vitro treatment with aryltriazene derivatives, Cancer Immunol. Immunother. 16:157 (1984).

    Article  CAS  Google Scholar 

  12. C. Riccardi, M. C. Fioretti, A. Giampietri, A. Puccetti, and A. Goldin, Growth rejection patterns of murine lymphoma cells antigenically altered following drug treatment in vivo, Transplantation 25:63 (1978).

    Article  PubMed  CAS  Google Scholar 

  13. L. Romani, M.C. Fioretti, E. Bonmassar, In vitro generation of primary cytotoxic lymphocytes against L5178Y leukemia antigenically altered by 5-(3,3’-dimethyl-1-triazeno)imidazole-4-carboxamide, Transplantation 28:21 (1979).

    Article  Google Scholar 

  14. P. Puccetti, L. Romani, M. C. Fioretti, Chemical xenogenization of tumor cells, Trends Pharmacol. Sci. 6:485 (1985).

    Article  CAS  Google Scholar 

  15. A. Giampietri, M. C. Fioretti, A. Goldin, and E. Bonmassar, Drug-mediated antigenic changes in murine leukemic cells: antagonistic effect of quinacrine, an antimutagenic compound, J. Natl. Cancer Inst. 64:297 (1980).

    PubMed  CAS  Google Scholar 

  16. M. C. Fioretti, R. Bianchi, L. Romani, and E. Bonmassar, Drug-induced immunogenic changes of murine leukemia cells: dissociation of onset of resistance and emergence of novel immunogenicity, J. Natl. Cancer Inst. 71:1247 (1983).

    PubMed  CAS  Google Scholar 

  17. D. D. Beal, J. L. Skibba, W. A. Croft, S. M. Cohen, and G. T. Bryan, Carcinogenicity of the antineoplastic agent 5(3–3-dimethyl-1-triazeno)imidazole-4-carboxamide, and its metabolites in rats, J. Natl. Cancer Inst. 54:951 (1975).

    PubMed  CAS  Google Scholar 

  18. B. H. Venger, C. Hansch, G. J. Hatheway, and Y. U. Amrein, Ames test of 1(X-Phenyl)3-3-dialkyltriazenes. A quantitative structure-activity study, J. Med. Chem. 22:473 (1979).

    Article  PubMed  CAS  Google Scholar 

  19. B. Nardelli, P. Puccetti, L. Romani, G. Sava, E. Bonmassar, and M. C. Fioretti, Chemical xenogenization of murine lymphoma cells with triazene derivatives: immunotoxicological studies, Cancer Immunol. Immunother. 17:213 (1984).

    Article  PubMed  CAS  Google Scholar 

  20. M. C. Fioretti, Immunopharmacology of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC), Pharmacol. Res. Comm. 7:481 (1975).

    Article  CAS  Google Scholar 

  21. A. Giampietri, and E. Bonmassar, Drug induced modulation of immune responses in mice, effects of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) and cyclophosphamide (CY), J. Immunopharmacol. 1:61 (1978).

    Article  PubMed  Google Scholar 

  22. P. A. Puccetti, and M. C. Giampietri, Long term depression of two primary immune responses induce by a single dose of DTIC, Experientia 34:799 (1978).

    Article  PubMed  CAS  Google Scholar 

  23. A. Giampietri, A. Bonmassar, P. Puccetti, A. Circolo, A. Goldin, and E. Bonmassar, Drug-mediated increase of tumor immunogenicity in vivo for a new approach to experimental cancer immunotherapy, Cancer Res. 41:681 (1981).

    PubMed  CAS  Google Scholar 

  24. O. Leo, D.H. Foo, L.E. Sacks, and J.A. Bluestone, Identification of a monoclonal antibody specific for a murine T3 polipeptide, Proc. Natl. Acad. Sci. 84:1374 (1987).

    Article  PubMed  CAS  Google Scholar 

  25. G. R. Ortega, R.J. Robb, E.M. Shevach, and T.R. Malek, The murine IL-2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cell and react with activated B cells, J. Immunol. 133:1970 (1984).

    PubMed  CAS  Google Scholar 

  26. A. Boyum A., Isolation of lymphocytes from human blood. Further observation. Methylcellulose, dextran and ficoll as erythrocyte aggregating agents, Scand. J. Clin. Invest. 21:31 (1968).

    CAS  Google Scholar 

  27. H. Wagner, C. Heeg, and Hardt C, Multiple signals required in cytolytic T cell responses, in: “Progress in Immunology VI”, L. Brent and J. Harborow eds., Academic Press Inc., (1986).

    Google Scholar 

  28. H. C. Wagner, C. Hardt, K. Heeg, K. Pfiezenmaier, W. Solbach, R. Bartlett, H. Stockinger, and M. Rollinghoff, T-T cell interactions during cytotoxic T lymphocyte (CTL) responses: T cell derived helper factor (Interleukin-2) as a probe to analyze CTL responsiveness and thymic maturation of CTL progenitors, Immunol. Rev. 51:215 (1980).

    Article  PubMed  CAS  Google Scholar 

  29. E. A. Valdstein, C. E. H. Cao, M. A. Bender, and R. R. Setlow, Abilities of extracts of human lymphocytes to remove O6-methyl guanine from DNA, Mut. Res. 95:405 (1982).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Experimental Medicine, CNR, Rome, Italy

    Stefania D’Atri, Lucio Tentori & Maria Tricarico

  2. Department of Experimental Medicine and Biochemical Sciences, II University of Rome, Rome, Italy

    Enzo Bonmassar

Authors
  1. Stefania D’Atri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lucio Tentori
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maria Tricarico
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Enzo Bonmassar
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Istituto di Farmacologia, Università di Trieste, 34127, Trieste, Italy

    Tullio Giraldi

  2. Toxicology Unit, Medical Research Council, Woodmansterne Road, SM5 4EF, Carshalton, Surrey, UK

    Thomas A. Connors

  3. Divisione di Oncologia Medica, Ospedale S. Maria della Misericordia, 33100, Udine, Italy

    Giuseppe Cartei

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Science+Business Media New York

About this chapter

Cite this chapter

D’Atri, S., Tentori, L., Tricarico, M., Bonmassar, E. (1990). Effects of Triazenes on Immune Responses. In: Giraldi, T., Connors, T.A., Cartei, G. (eds) Triazenes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3832-5_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3832-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6710-9

  • Online ISBN: 978-1-4615-3832-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation