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Antimestastatic Action of Triazene Derivatives

  • Chapter
Triazenes

Abstract

Dimethyltriazenes have gained, since the original observation in 1962 by Shealy et al. on the antitumor action of DTIC in mice (1), a definite position among antineoplastic drugs because of the established activity of DTIC against human malignant melanoma, as well as against other human malignancies when used in combination with other antitumor drugs. Substituted benzenoid dimethyltriazenes have also been thoroughly examined in experimental animal tumor systems, and selected compound(s) are currently under clinical trials as second generation substitutes for DTIC (see other chapters in this volume).

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  1. Tullio Giraldi (Cattedra di Farmacologia)

    Present address: Cattedra di Farmacologia, Istituto di Biologia, Facoltà di Medicina, Università di Udine, I-33100, Udine, Italy

Authors and Affiliations

  1. Istituto di Farmacologia, Università di Trieste, I-34100, Trieste, Italy

    Tullio Giraldi (Cattedra di Farmacologia), Laura Perissin, Sonia Zorzet & Valentina Rapozzi

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  1. Tullio Giraldi
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  2. Laura Perissin
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  3. Sonia Zorzet
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Editors and Affiliations

  1. Istituto di Farmacologia, Università di Trieste, 34127, Trieste, Italy

    Tullio Giraldi

  2. Toxicology Unit, Medical Research Council, Woodmansterne Road, SM5 4EF, Carshalton, Surrey, UK

    Thomas A. Connors

  3. Divisione di Oncologia Medica, Ospedale S. Maria della Misericordia, 33100, Udine, Italy

    Giuseppe Cartei

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Giraldi, T., Perissin, L., Zorzet, S., Rapozzi, V. (1990). Antimestastatic Action of Triazene Derivatives. In: Giraldi, T., Connors, T.A., Cartei, G. (eds) Triazenes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3832-5_4

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