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Mechanisms of the Biological Actions of Triazenes

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Triazenes

Abstract

5-(3,3-Dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC, Fig. 1) was the first member of the series of antitumour triazenes and was chosen for clinical trial because of its activity against murine leukaemia L1210. Significant activity was demonstrated against malignant melanoma with an overall response rate of 21%, while marginal activity was demonstrated against other solid tumours.

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Author information

Authors and Affiliations

  1. Cancer Research Campaign Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, B4 7ET, UK

    M. J. Tisdale

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  1. M. J. Tisdale
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Editor information

Editors and Affiliations

  1. Istituto di Farmacologia, Università di Trieste, 34127, Trieste, Italy

    Tullio Giraldi

  2. Toxicology Unit, Medical Research Council, Woodmansterne Road, SM5 4EF, Carshalton, Surrey, UK

    Thomas A. Connors

  3. Divisione di Oncologia Medica, Ospedale S. Maria della Misericordia, 33100, Udine, Italy

    Giuseppe Cartei

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© 1990 Springer Science+Business Media New York

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Tisdale, M.J. (1990). Mechanisms of the Biological Actions of Triazenes. In: Giraldi, T., Connors, T.A., Cartei, G. (eds) Triazenes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3832-5_2

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  • DOI: https://doi.org/10.1007/978-1-4615-3832-5_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6710-9

  • Online ISBN: 978-1-4615-3832-5

  • eBook Packages: Springer Book Archive

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