Abstract
Colonization of an animal host by a disease causing bacterial species involves a complex sequence of events that includes bacterial entry and multiplication, sometimes with damage to the host.1 At each step the host has placed barricades that initiate various host vs. microbe conflicts on which the outcome of the invasion is balanced. Competition for iron is a key biofulcrum.2 The winner of the iron battle may not ultimately win the war but the absolute nutritional requirement of the bacteria for iron means that the microbe will never win without capturing the metal from its host. Identifying the iron retention and iron gathering weapons used by the two competitors constitutes a fascinating, and still incomplete, study. The techniques of modern molecular biology enable more precise determination of the bacterial iron related virulence molecules and the genes encoding their synthesis. While some general bacterial iron acquisition modes are evident, the tactics employed by different bacteria have to be defined on a case-by-case basis. With detailed knowledge of the bacterial systems, it may be possible to devise the means for enhancing the host’s iron withholding defenses.
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Byers, B.R., Arceneaux, J.E.L., Barghouthi, S., Massad, G., Zywno, S. (1991). Iron Acquisition and Microbial Virulence: Potential Uptake Systems in the Aeromonas Species. In: Frankel, R.B., Blakemore, R.P. (eds) Iron Biominerals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3810-3_30
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DOI: https://doi.org/10.1007/978-1-4615-3810-3_30
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