Abstract
The basic philosophy of structure-activity relationship studies is to draw conclusions by analogy. We assume that similar chemical properties of drugs will result in similar biological responses. The problem consists of identifying exactly what these properties are, and how they are connected with the biological activity of interest. Attempts to correlate structure with biological activity date back to the last century. These attempts were essentially qualitative, or semi-quantitative. In the sixties there was a great progress towards the establishment of a Quantitative Structure-Activity Relationship (QSAR) science. This transformation has happened in the field of medicinal chemistry because of the pioneering work of Hansch.
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Benigni, R. (1990). Quantitative Structure-Activity Relationships, and Mutagens and Carcinogens. In: Kappas, A. (eds) Mechanisms of Environmental Mutagenesis-Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3808-0_16
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DOI: https://doi.org/10.1007/978-1-4615-3808-0_16
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