Fibrinogen Proteolysis and Coagulation System Activation during Thrombolytic Therapy

  • John Owen
  • Betty Grossman
  • Joan Sobel
  • Bohdan Kudryk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 281)


Thrombolytic treatment of patients with acute myocardial infarction is now well accepted as the treatment of choice in most settings (24). At this time most data has been accumulated with the use of streptokinase, and this drug has been convincingly demonstrated to reduce mortality (5). Reperfusion is achieved in 45–75% of patients, with direct intracoronary administration being slightly more effective than administration by the intravenous route (25). Some problems remain, bleeding is significant and rethrombosis continues to be an obstacle (7).


Acute Myocardial Infarction Thrombolytic Therapy Tissue Plasminogen Activator Plasmin Action Intracoronary Streptokinase 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • John Owen
    • 1
    • 2
    • 3
  • Betty Grossman
    • 1
    • 2
    • 3
  • Joan Sobel
    • 1
    • 2
    • 3
  • Bohdan Kudryk
    • 1
    • 2
    • 3
  1. 1.The Bowman Gray School of MedicineWake Forest UniversityWinston-SalemUSA
  2. 2.The College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.the Lindsley E. Kimball Research Institute of the New York Blood CenterNew YorkUSA

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