Clinical Application of Tissue Plasminogen Activator Therapy in Acute Myocardial Infarction

  • Shih-Pu Wang
  • Mau-Song Chang
  • Benjamin N. Chiang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 281)


Acute myocardial infarction is related to plaque rupture and thrombosis formation in the infarct-related coronary artery. Salvage of ischemic area with thrombolysis in the early stage of infarction has proved to be the best way to limit infarct size, preserve left ventricular function and reduce mortality in the majority of victims. Tissue plasminogen activator (tPA) is the most promising thrombolytic agent used to salvage ischemic myocardium; the efficacy has been systematically demonstrated in previous studies (1–4).


Acute Myocardial Infarction Thrombolytic Therapy Patency Rate Activate Partial Thromboplastin Time Coronary Arteriography 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Shih-Pu Wang
    • 1
  • Mau-Song Chang
    • 1
  • Benjamin N. Chiang
    • 1
  1. 1.Division of CardiologyVeterans General Hospital and Yang-Ming Medical CollegeTaipeiTaiwan, ROC

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