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Modern Strategies for Treatment of Acute Myocardial Infarction: Significance of Haemostaseological and Rheological Findings

  • G. Pindur
  • C. Sen
  • E. Wenzel
  • F. Jung
  • C. Özbek
  • H. Schwerdt
  • H. Schieffer
  • L. Bette
  • C. Miyashita
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 281)

Abstract

In spite of equivalent clinical efficacy of various thrombolytic agents for the treatment of acute myocardial infarction there is evidence of different drug-depending influences on the haemostatic and fibrinolytic system. In the present study 40 patients with acute myocardial infarction have been investigated. 20 patients received 750,000 and 1.5 mio U streptokinase (SK), respectively, 10 patients 30 mg anisoylated plasminogen streptokinase activator complex (BRL 26921) and 10 patients a combination of 200,000 U urokinase (UK) and 4.5 mio U pro-urokinase (PUK) as a short-term intravenous treatment. Reperfusion of coronary arteries has been achieved in 70 to 100 percent. Major not fatal bleedings occurred in 2 patients. One patient died within 72 hours after beginning of the myocardial infarction. The longest duration of fibrinolytic activity was observed in the BRL 26921 group (half-disappearance time close to 2 h). It was significantly shorter in the SK groups showing a dose-dependency. Plasma concentration of fibrinogen dropped beyond normal levels following SK and BRL 26921, but not under UK/PUK. Plasma viscosity correlated with fibrinogen decrease and displayed a dose-depending relationship with the presence of SK. Haemorheological effects are suggested to be important for the clinical efficacy of thrombolytic therapy in myocardial infarction.

Keywords

Acute Myocardial Infarction Acute Myocardial Infarction Thrombolytic Therapy Fibrinolytic Activity Activate Partial Thromboplastin Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • G. Pindur
    • 1
  • C. Sen
    • 2
  • E. Wenzel
    • 1
  • F. Jung
    • 1
  • C. Özbek
    • 2
  • H. Schwerdt
    • 2
  • H. Schieffer
    • 2
  • L. Bette
    • 2
  • C. Miyashita
    • 1
  1. 1.Abteilung für Klinische Haemostaseologie und TransfusionsmedizinMedizinische Universitätsklinik und Poliklinik,Innere Medizin IIIGermany
  2. 2.Innere Medizin IIIUniversitätskliniken Homburg/SaarGermany

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