The Effects of Streptokinase and Tissue Plasminogen Activator on Left Ventricular Function

  • Harvey D. White
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 281)


One of the major questions remaining in thrombolysis is which drug we should be using. In terms of “head to head” comparisons there are few data. Streptokinase and tissue plasminogen activator have been compared in terms of patency and tissue plasminogen activator has been shown to be superior (1, 2). However, patency cannot be directly extrapolated to patient benefit and direct comparisons of the effects of these drugs on left ventricular function and mortality are required. Left ventricular function can be considered as a surrogate for mortality but in addition the assessment of left ventricular function also evaluates the capacity of a patient to exercise, and relates to quality of life. In this study the effects of streptokinase and tissue plasminogen activator on left ventricular function were compared.


Left Ventricular Function Tissue Plasminogen Activator Intravenous Streptokinase Left Main Disease Intracoronary Streptokinase 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Harvey D. White
    • 1
  1. 1.Cardiovascular ResearchGreen Lane HospitalAucklandNew Zealand

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