On the Identity of Fibrin(ogen) Oligomers Appearing during Fibrin Polymerization
Fibrinogen (1) is a dimeric, symmetrical molecule with the overall structure (Aα, Bβ, γ)2. When fibrinogen is converted into fibrin by the action of thrombin two moles of each fibrinopeptide A and B are finally released. Hereby four N-terminal polymerization sites are revealed in each molecule and these can then interact with four pre-existing C-terminal polymerization sites so that fibrin oligomers and polymers are formed. It is well established that A-peptides are removed from fibrinogen before B-peptides and that A-peptide release alone is sufficient for clotting to occur. The two fibrin types formed have the structures [(α, β, γ)2]n and [(α, Bβ, γ)2]n respectively.
KeywordsCyanogen Bromide Elution Pattern Soluble Oligomer Symmetrical Molecule Fibrin Polymerization
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