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Nucleotide Sequences of the Three Genes Coding for Human Fibrinogen

  • Dominic W. Chung
  • Jeff E. Harris
  • Earl W. Davie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 281)

Abstract

Fibrinogen is synthesized in the liver by hepatic parenchymal cells and is secreted into the circulation (1). Hepatic synthesis of fibrinogen is constitutive but the rate can be modulated by a number of physiological and nonphysiological factors. The three chains of fibrinogen are encoded by distinct species of mRNA that are derived from the expression of three single copy genes (2, 3). Present evidence indicates that the three genes of human fibrinogen are linked and are located in a region that extends approximately 45 kb on chromosome 4q23-q32 (4). The genes are arranged in the order of γ-Aα-Bβ. The γ and Aα genes are transcribed in the same direction while the Bβ gene is transcribed in the opposite direction.

Keywords

Human Fibrinogen 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Dominic W. Chung
    • 1
  • Jeff E. Harris
    • 1
  • Earl W. Davie
    • 1
  1. 1.Department of BiochemistryUniversity of WashingtonSeattleUSA

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