The Regulation of the Activaton of the Fibrinolysis System

  • A. Takada
  • T. Urano
  • Y. Takada
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 281)


Fibrinolysis is a system in which fibrin clot dissolves due to the degradation of fibrin by plasmin, which is present in the blood as a precursor form, plasminogen (plg). A native form of plasminogen has glutamic acid at its N-terminus, and called as Glu-plg. Plasminogen is activated to plasmin by a group of enzymes, called plasminogen activators (PA). There are two pathways in the fibrinolysis system: the intrinsic pathway initiates upon the activation of a coagulation factor XII to XIIa in its interaction with a negatively charged foreign surface in the presence of high molecular weight kininogen and prekallikrein, and the other pathway, extrinsic pathway, initiates by PAs introduced in the blood exogenously from endothelial cells or upon the addition of bacterial activators such as streptokinase (SK).


Plasminogen Activator Tissue Plasminogen Activator Tranexamic Acid Fibrinolysis System Chain Form 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • A. Takada
    • 1
  • T. Urano
    • 1
  • Y. Takada
    • 1
  1. 1.Department of PhysiologyHamamatsu University School of MedicineHamamatsu-shi, ShizuokaJapan

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