Thrombin Inhibition by Synthetic Hirudin Peptides

  • John M. Maraganore
  • John W. FentonII
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 281)


Thrombin (EC is a central, bioregulatory enzyme in thrombosis and hemostasis (1, 2). Thrombin activities are diverse and include fibrin clot formation (3) and stabilization (4), platelet and other cellular activation (5–7), and both positive and negative control of its own zymogen activation (8, 9). When compared to other serine proteinases of the coagulation and fibrinolytic systems, thrombin is unique in lacking the majority of its propiece (prothrombin fragment F 1.2) following zymogen activation (10, 11). Accordingly, the various specificities of thrombin must be accommodated solely within the enzyme moiety consisting of A and B chains.


Anticoagulant Activity Prothrombin Fragment Catalytic Pocket Antithrombin Activity Zymogen Activation 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • John M. Maraganore
    • 1
  • John W. FentonII
    • 2
  1. 1.Biogen, Inc.CambridgeUSA
  2. 2.Wadsworth Center for Laboratories and Research New York State Department of Health Departments of Physiology and BiochemistryThe Albany Medical College of Union UniversityAlbanyUSA

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