Factor VII and Dietary Fat Intake

  • G. J. Miller
  • J. C. Martin
  • K. A. Mitropoulos
  • J. K. Cruickshank
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 281)


Evidence for an increased factor VII coagulant activity (VIIc) in acute myocardial infarction was first provided by Poller in 1957 (1). In this study a group of 20 patients examined within 48 hours of onset of an acute thrombotic episode (18 were cases of coronary thrombosis) had a significantly higher mean VII, than control subjects. This finding has since been confirmed by some (2, 3) but not all (4) more recent studies.


Serum Triglyceride Concentration Northwick Park Hospital Bovine Factor Northwick Park Heart Study High VIle 
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  1. 1.
    L. Poiler, Thrombosis and factor VII activity, J. Clin. Path.,10:348–350 (1957).CrossRefGoogle Scholar
  2. 2.
    J. Carvalho de Sousa, J. Azevedo, C. Soria, F. Barros, C. Ribeiro, F. Parreira, and J. P. Caen, Factor VII hyperactivity in acute myocardial thrombosis. A relation to the coagulation activation, Thromb. Res., 51:165–173 (1988).PubMedCrossRefGoogle Scholar
  3. 3.
    C. J. Hoffman, R. H. Miller, W. E. Lawson, and M. B. Hultin, Elevation of factor VII activity and mass in ischemic heart disease and in young subjects at high risk of ischemic heart disease, Circulation, 78 (Suppl. II):316 (1988).Google Scholar
  4. 4.
    P. M. Sandset, P. A. Sirnes, and U. Abildgaard, Factor VII and extrinsic pathway inhibitor in acute coronary disease, Br. J. Haematol., 72:391–396 (1989).PubMedCrossRefGoogle Scholar
  5. 5.
    T. W. Meade, S. Mellows, M. Brozovic, G. J. Miller, R. R. Chakrabarti, W. R. S. North, A. P. Haines, Y. Stirling, J. D. Imeson, and S. G. Thompson, Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study, Lancet, 2:533–537 (1986).PubMedCrossRefGoogle Scholar
  6. 6.
    A. Keys, J. T. Anderson, and F. Grande, Serum cholesterol response to changes in the diet, Metabolism,14:747–787 (1965).CrossRefGoogle Scholar
  7. 7.
    D. M. Hegsted, R. B. McGandy, M. L. Myers, and F. J. Stare, Quantitative effects of dietary fat on serum cholesterol in men, Am. J. Clin. Nutr.,17:281–295 (1965).PubMedGoogle Scholar
  8. 8.
    J. W. Marr, Individual dietary surveys — purposes and methods, World Rev. Nutr. Diet.,13:105–164 (1971).PubMedGoogle Scholar
  9. 9.
    A. A. Paul, and D. A. T. Southgate, McCance and Widdowson’s The Composition of Foods, 4th revised and extended edition of MRC special report No. 297, HMSO, London (1978).Google Scholar
  10. 10.
    G. J. Miller, J. C. Martin, J. Webster, H. C. Wilkes, N. E. Miller, W. H. Wilkinson, and T. W. Meade, Association between dietary fat intake and plasma factor VII coagulant activity — a predictor of cardiovascular mortality, Atherosclerosis, 60:269277 (1986).Google Scholar
  11. 11.
    G. J. Miller, M. J. Seghatchian, S. J. Walter, D. J. Howarth, S. G. Thompson, M. P. Esnouf, and T. W. Meade, An association between the factor VII coagulant activityand thrombin activity induced by surface/cold exposure of normal human plasma, Br. J. Haematol.,62:379–384 (1986).PubMedCrossRefGoogle Scholar
  12. 12.
    G. J. Miller, J. K. Cruickshank, L. V. Ellis, R. L. Thompson, H. C. Wilkes, Y. Stirling, K. A. Mitropoulos, J. V. Allison, T. E. Fox, and A. O. Walker, Fat consumption and factor VII coagulant activity in middle-aged men. An association between a dietary and thrombogenic coronary risk, factor, Atherosclerosis, 78:19–24 (1989).PubMedCrossRefGoogle Scholar
  13. 13.
    M. Brozovic, Y. Stirling, C. Harricks, W. R. S. North, and T. W. Meade, Factor VII in an industrial population, Br. J. Haematol.,28:381–391 (1974).PubMedCrossRefGoogle Scholar
  14. 14.
    K. A. Mitropoulos, M. P. Esnouf, and T. W. Meade, Increased factor VII coagulant activity in the rabbit following diet-induced hypercholesterolaemia. Evidence for increased conversion of VII to αVIIa and higher flux within the coagulation pathway, Atherosclerosis, 63:43–52 (1987).PubMedCrossRefGoogle Scholar
  15. 15.
    R. D. Radcliffe, A. Bagdasarian, R. W. Colman, and Y. Nemerson, Activation of bovine factor VII by Hageman factor fragments, Blood, 50:611–617 (1977).PubMedGoogle Scholar
  16. 16.
    U. Seligsohn, B. Osterud, S. F. Brown, J. H. Griffin, and S. I. Rapaport, Activation of human factor VII in plasma and in purified systems. Roles of activated factor IX, kallikrein and activated factor XII, J. Clin. Invest., 64:1056–1065 (1979).PubMedCrossRefGoogle Scholar
  17. 17.
    K. A. Mitropoulos, J. C. Martin, B. E. A. Reeves, and M. P. Esnouf, The activation of the contact phase of coagulation by physiologic surfaces in plasma: the effect of large negatively charged liposomal vesicles, Blood,73:1525–1533 (1989).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • G. J. Miller
    • 1
  • J. C. Martin
    • 1
  • K. A. Mitropoulos
    • 1
  • J. K. Cruickshank
    • 1
  1. 1.Medical Research Council, MRC Epidemiology and Medical Care UnitNorthwick Park HospitalHarrow MiddlesexUK

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