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Mutations Induced in the lacI Gene of E. coli by 1-Nitroso-8-Nitropyrene and Furylfuramide: The Influence of Plasmid pKM101 and Excision Repair on the Mutational Spectrum

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Nitroarenes

Part of the book series: Environmental Science Research ((ESRH,volume 40))

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Abstract

Nitrated polyaromatic hydrocarbons (NO2PAH) and nitroheterocyclic compounds are of potential human health importance. NO2PAH are emitted into the environment as byproducts of combustion processes (1), while nitroheterocyclic compounds such as 5-nitrofuran derivatives have been widely used in both human and veterinary medicine, and as food additives and preservatives. Representatives of each of these chemical classes are potent mutagens in bacteria, and induce tumors in rodents (1,2).

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Author information

Authors and Affiliations

  1. McMaster University, Hamilton, Ontario, Canada

    I. B. Lambert, T. A. Chin, D. W. Bryant & D. R. McCalla

  2. York University, Toronto, Ontario, Canada

    A. J. E. Gordon & B. W. Glickman

Authors
  1. I. B. Lambert
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  2. A. J. E. Gordon
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  3. T. A. Chin
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  4. D. W. Bryant
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  5. B. W. Glickman
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  6. D. R. McCalla
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Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Paul C. Howard

  2. American Health Foundation, Valhalla, New York, USA

    Stephen S. Hecht

  3. National Center for Toxicological Research, Jefferson, Arkansas, USA

    Frederick A. Beland

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© 1990 Springer Science+Business Media New York

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Lambert, I.B., Gordon, A.J.E., Chin, T.A., Bryant, D.W., Glickman, B.W., McCalla, D.R. (1990). Mutations Induced in the lacI Gene of E. coli by 1-Nitroso-8-Nitropyrene and Furylfuramide: The Influence of Plasmid pKM101 and Excision Repair on the Mutational Spectrum. In: Howard, P.C., Hecht, S.S., Beland, F.A. (eds) Nitroarenes. Environmental Science Research, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3800-4_15

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  • DOI: https://doi.org/10.1007/978-1-4615-3800-4_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6694-2

  • Online ISBN: 978-1-4615-3800-4

  • eBook Packages: Springer Book Archive

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