Abstract
The B-cell immune response is initiated in vivo by antigen binding to antigen-specific membrane immunoglobulin (mIg) molecules. Binding leads to antigen uptake, processing by proteases, and reexpression, now as immunogenic peptides in association with major histocompatibility complex, (MHC)-encoded class II (Ia) molecules (for a review, see Chesnut and Grey, 1986; Rock et al., 1984). Antigen binding to mIg also leads to signal transduction stimulating alterations in various cellular processes of the B cell (for a review, see Cambier and Ransom, 1987; DeFranco, 1987). Depending on its structure, binding of antigen to B-cell mlg may at one extreme provide a stimulus sufficient to induce expression of a large complex of genes that cause B-cell proliferation and differentiation into antibody-secreting plasma cells or, alternatively, it may stimulate expression of only a limited set of genes (Cambier and Ransom, 1987; DeFranco, 1987; Finkelman et al., 1986).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abbas, A. K., 1988, A reassessment of the mechanism of antigen-specific T-cell-dependent B-cell activation, Immunol. Today 89:94
Albrecht, D. L., and Noelle, R. J., 1988, Membrane Ig-cytoskeletal interactions. I. Flow cytofluorometric and biochemical analysis of IgM-cytoskeletal interactions, J. Immunol. 141:3915–3922
Bijsterbosch, M., Meade, J. C., Turner, G. A., and Klaus, G. G. B., 1985, B lymphocyte receptors and polyphosphoinositide degradation, Cell 41:999–1006
Bijsterbosch, M. K., Rigley, K. P., and Klaus, G. G. B., 1986, Crosslinking of surface immunoglobulin on B lymphocytes induces intracellular Ca+ + release and Ca+ + influx: Analysis with Indo-1, Biochem. Biophys. Res. Commun. 137:500–506
Bishop, G. A., and Haughton, G., 1986, Induction of differentiation of a transformed clone of Lyl+ B cells by clonal T cells and antibodies, Proc. Natl. Acad. Sci. USA 83:7410–7414
Braun, J., and Unanue, E. R., 1980, B lymphocyte biology studied with anti-Ig antibodies, Immunol. Rev. 52:3–28
Brian, A. A., 1988, Stimulation of B-cell proliferation by membrane-associated molecules from activated T cells, Proc. Natl. Acad. Sci. USA 85:564–568
Cambier, J. C., and Julius, M. H., 1988, Early changes in quiescent B cell physiology subsequent to cognate and bystander interaction with helper T cells, Scand. J. Immunol. 27:59–71
Cambier, J. C., and Lehmann, K. L., 1989, Ia mediated signal transduction leads to proliferation of primed B lymphocyte, J. Exp. Med. 170:877–886
Cambier, J. C., and Ransom, J. T., 1987, Molecular mechanisms of transmembrane signaling in B lymphocytes, Annu. Rev. Immunol. 5:179–199
Cambier, J. C., Monroe, J. G., and Neale, M. J., 1982, Definition of conditions which facilitate antigen specific activation of the majority of isolated trinitrophenol binding B cells, J. Exp. Med. 156:1635–1649
Cambier, J. C., Heusser, C. H., and Julius, M. H., 1986, Abortive activation of B lymphocytes by anti-immunoglobulin antibodies, J. Immunol. 136:3140–3146
Cambier, J. C., Newell, M. K., Justement, L. B., McGuire, J. C., Leach, K. L., and Chen, Z. Z., 1987, Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes, Nature (London) 327:629–632
Chen, Z. Z., Coggeshall, K. M., and Cambier, J. C., 1986, Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes, J. Immunol. 136:2300–2306
Chen, Z. Z., McGuire, J. C., Leach, K. L., and Cambier, J. C., 1987, Transmembrane signaling through B cell MHC class II molecules: Anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction, J. Immunol. 138:2345–3252
Chesnut, R. W., and Grey, H. M., 1986, Antigen presentation by B cells and its significance in T-B interactions, Adv. Immunol. 39:51–94
Clement, L. T., Tedder, T. F., and Gartland, G. L., 1986, Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation, J. Immunol. 136:2375–2381
Coggeshall, K. M., and Cambier, J. C., 1984, B cell activation. VIII. Membrane immunoglobulins transducer signals via activation of phosphatidylinositol hydrolysis, J. Immunol. 133:3382–3386
Cohen, D. P., and Rothstein, T. L., 1989, Adenosine 3’, 5’-cyclic monophosphate modulates the mitogenic responses of murine B lymphocytes, Cellular Immunol. 121:113–124
DeFranco, A. L., 1987, Molecular aspects of B-lymphocyte activation, Annu. Rev. Cell Biol. 3:143–78
DeFranco, A. L., Ashwell, J. D., Schwartz, R. H., and Paul, W. E., 1984, Polyclonal stimulation of resting B lymphocytes by antigen specific T lymphocytes, J. Exp. Med. 159:861–880
DeFranco, A. L., Ravache, E. S., and Paul, W. E., 1985, Separate control of B lymphocyte early activation and proliferation in response to anti-IgM antibodies, J. Immunol. 135:87–94
Doyle, C., and Strominger, J. L., 1987, Interaction between CD4 and class II MHC molecules mediates cell adhesion, Nature (London) 330:256–259
Figueroa, F., and Klein, J., 1986, The evolution of class II MHC genes, Immunol. Today 7:78–79
Finkelman, F. D., Mond, J. J., and Metcalfe, E. S., 1986, Anti-immunoglobulin antibody induction of B lymphocyte activation and differentiation, in B-Lymphocyte Differentiation (J. Cambier, ed.), pp. 41–61, CRC Press, Boca Raton, Fla.
Gay, D., Maddon, P., Sekaly, R., Talle, M. A., Godfrey, M., Long, E., Goldstein, G., Chess, L., Axel, R., Kappler, J., and Marrack, P., 1987, Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen, Nature (London) 328:626–629
Goroff, D. K., Stall, A., Mond, J. J., and Finkelman, F. D., 1986, In vitro and in vivo B lymphocyte-activating properties of monoclonal anti-α antibodies. I. Determinants of B lymphocyte-activating properties, J. Immunol. 136:2382–2392
Grupp, S. H., Snow, E. C., and Harmony, A. K., 1987, Phosphatidylinositol response is an early event in physiologically relevant activation of antigen specific B lymphocytes, Cell. Immunol. 109:181–191
Hirohata, S., Jelinek, D. F., and Lipsky, P. E., 1988, T cell-dependent activation of B cell proliferation and differentiation by immobilized monoclonal antibodies to CD3, J. Immunol. 140:3726–3744
Hombeck, P., and Paul, W. E., 1986, Anti-immunoglobulin and phorbol ester induce phosphorylation of proteins associated with plasma membrane and cytoskeleton in murine B lymphocytes, J. Biol. Chem. 261:14817–14824
Julius, M. H., and Rammensee, H.-G., 1988, T helper cell-dependent induction of resting B cell differentiation need not require cognate cell interactions, Eur. J. Immunol. 18:375–379
Julius, M., Von Boehmer, H., and Sidman, C. L., 1982, Dissociation of two signals required for activation of resting B cells, Proc. Natl. Acad. Sci. USA 79:1989–1993
Julius, M. H., Heusser, C. H., and Hartmann, K.-U., 1984, Induction of resting B cells to DNA synthesis by soluble monoclonal anti-immunoglobulin, Eur. J. Immunol. 14:753–757
Kikkawa, U., Ogita, K., Ono, Y., Asaoka, Y., Shearman, J. S., Tomoko, F., Ase, K., Sekiguchi, K., Igarashi, K., and Nishizuka, K., 1987, The common structure and activities of four subspecies of rat brain protein kinase C family, FEBS Lett. 223:212–216
Klaus, G. G. B., O’Garra, A., Bijsterbosch, M. K., and Holman, M., 1986, Activation and proliferation signals in mouse B cells. VIII. Induction of DNA synthesis in B cells by a combination of calcium ionophores and phorbol myristate acetate, Eur. J. Immunol. 16:92–97
Klemsz, M. J., Palmer, E., and Cambier, J., 1990, B cell activation. IX. Different control mechanisms are operative in anti-Ig and BSF1 induction of increased Ia mRNA and surface expression (submitted for publication)
Klemsz, M. J., Justement, L. B., Palmer, E., and Cambier, J. C., 1989, Induction of c-fos and c-myc expression during B cell activation, J. Immunol. 143:1032–1040
Krusemeier, M., and Snow, C., 1988, Induction of lymphokine responsiveness of hapten-specific B lymphocytes promoted through an antigen-mediated T helper lymphocyte interaction, J. Immunol. 140:367–375
Kung, J. T., Sharrowm, S. O., Sieckman, D. G., Lieberman, R., and Paul, E. W., 1981, A mouse IgM allotypic determinant (Igh 51b) recognized by a monoclonal rat antibody, J. Immunol. 127:873–876
Kupfer, A., and Singer, S. J., 1989, Cell biology of helper T-cell functions, Annu. Rev. Immunol. 7:309–339
Kupfer, A., Swain, S. L., and Singer, S. J., 1987, The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorientation of the membrane-associated cytoskeleton inside the bound helper T cells, J. Exp. Med. 165:1565–1580
Leclercq, L., Bismuth, G., and Theze, J., 1984, Antigen specific helper T-cell supernatant is sufficient to induce both polyclonal proliferation and differentiation of small resting B lymphocytes, Proc. Natl. Acad. Sci. USA 81:6491–6495
Leclerq, L., Cambier, J. C., Mishel, Z., Julius, M. H., and Theze, J., 1986, Supernatants from a cloned helper T cell stimulates most small resting B cells to undergo increased I-A expression, blastogenesis and progression through cell cycle, J. Immunol. 136:539–545
Leptin, M., 1985, Monoclonal antibodies specific for murine IgM. II. Activation of B lymphocytes by mono-clonal antibodies specific for the four constant domains of IgM, Eur. J. Immunol. 15:131–137
MacDougall, S. L., Grinstein, S., and Gelfand, E. W., 1988, Detection of ligand-activated conductive Ca2+ channels in human B lymphocytes, Cell 54:229–234
Miles, K., Atweh, S., Otten, G., Amason, B. G. W., Chelmicka-Schorr, E., 1984, β-Adrenergic receptors on splenic lymphocytes from axotomized mice, Int. J. Immunopharmacol. 6:1171–1177
Mond, J. J., Feuerstein, N., Finkleman, F. D., Huang, F., Huang, K.-P., and Dennis, G., 1987, B-lymphocyte activation mediated by anti-immunoglobulin antibody in the absence of PKC, Proc. Natl. Acad. Sci. USA 89:8588–8592
Monroe, J. G., 1988, Up-regulation of c-fos expression is a component of the mlg signal transduction mecha-nisms but is not indicative of competence for proliferation, J. Immunol. 140:1454–1460
Mossman, T., 1983, Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay, J. Immunol. Methods 65:55–64
Myers, C. D., Kriz, M. K., Sullivan, T. J., and Vitetta, E. S., 1987, Antigen induced changes in phospholipid metabolism in antigen-binding B lymphocytes, J. Immunol. 138:1705–1711
Nel, A. D., Landroth, G. E., Goldschmidt-Clermont, P. J., Tuno, H. E., and Galbraith, R. M., 1984, Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin, Biochem. Biophys. Res. Commun. 125:859–866
Nel, A. E., Navailles, M., Rosberger, D. F., Landreth, G. E., Goldschmidt-Clermong, P. J., Baldwin, G. J., and Galbraith, R. M., 1985, Phorbol ester induces tyrosine phosphorylation in normal and abnormal human B lymphocytes, J. Immunol. 135:3448–3453
Nel, A. E., Wooten, M. W., Landreth, G. E., Goldschmidt-Clermont, P. J., Stevenson, H. C., Miller, P. J., and Galbraith, R. M., 1986, Translocation of phospholipid/Ca+ + -dependent protein kinase in B lymphocytes activated by phorbol ester or crosslinking of membrane immunoglobulin, Biochem. J. 233:145–149
Niederhuber, J. E., Frelinger, J. A., Dugan, E., Coutinho, A., and Shreffler, D. C., 1975, Effects of anti-Ia serum on mitogenic responses. I. Inhibition of proliferative response to B cell mitogen, LPS, by specific anti-Ia sera, J. Immunol. 115:1672–1676
Noelle, R. J., Snow, E. C., Uhr, J. W., and Vitetta, E. S., 1983, Activation of antigen-specific B cells: The role of T cells, cytokines and antigens in the induction of growth and differentiation, Proc. Natl. Acad. Sci. USA 80:6628–6631
O’Garra, A., Umland, S., DeFrance, T., and Christiansen, J., 1988, B-cell factors are pleiotropic, Immunol. Today 9:45–54
Oliver, K., Noelle, R., Uhr, J. W., Krammer, P. H., and Vitetta, E. S., 1985, B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not induce cell growth, Proc. Natl. Acad. Sci. USA 82:2465–2467
Owen, T., 1988, A noncognate interaction with anti-receptor antibody-activated helper T cells induces small resting mucine B cells to proliferate and to secrete antibody, Eur. J. Immunol. 18:395–401
Palacios, R., Martinez-Maza, O., and Guy, K., 1983, Monoclonal antibodies against HLA-DR antigens replace T helper cells in activation of B lymphocytes, Proc. Natl. Acad. Sci. USA 80:3456–3460
Plaut, M., 1987, Lymphocyte hormone receptors, Annu. Rev. Immunol. 5:621–671
Poo, W.-J., Conrad, L., and Janeway, C. A., Jr., 1988, Receptor-directed focusing of lymphokine release by helper T cells, Nature (London) 332:370–380
Ransom, J. T., Chen, M., Sandoval, V. M., Pasternak, J. A., DiGiusto, D., and Cambier, J. C., 1988, Increased plasma membrane permeability to Ca2+ in anti-Ig-stimulated B lymphocytes is dependent on activation of phosphoinositide hydrolysis, J. Immunol. 140:3150–3155
Riedel, C., Owens, T., and Nossal, G. J. V., 1988, A significant proportion of normal resting B cells are induced to secrete immunoglobulin through contact with anti-receptor antibody-activated helper T cells in clonal cultures, Eur. J. Immunol. 18:403–408
Rock, K. L., Benacerraf, B., and Abbas, A. R., 1984, Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors, J. Exp. Med. 160:1102–1113
Rothstein, T. L., Backer, T. R., Miller, R. A., and Kulber, D. L., 1986, Stimulation of mucine B cells by the combination of calcium ionophore plus phorbol ester, Cell. Immunol. 102:364–373
Sanders, V. M., Dernandez-Bottran, R., Uhr, J. W., and Vitetta, E. S., 1987, Interleukin 4 enhances the ability of the antigen-specific B cells to form conjugates with T cells, J. Immunol. 139:2349–2354
Schreiner, G. F., and Unanue, E. R., 1976, Membrane and cytoplasmic changes in B lymphocytes induced by ligand-surface immunoglobulin interactions, Adv. Immunol. 24:38–165
Shivdasani, R. A., and Thomas, D. W., 1988, Molecular associations of la antigens after T-B cell interactions. I. Identification of new molecular associations, J. Immunol. 141:1252–1260
Singer, A., and Hodes, R. J., 1983, Mechanisms of T cell-B cell interaction, Annu. Rev. Immunol. 1:211–241
Snapper, C. M., and Paul, W. E., 1987, B cell stimulator factor-1 (interleukin 4) prepares resting mucine B cells to secrete IgG1 upon stimulation with bacterial lipopolysaccharide, J. Immunol. 139:10–17
Snow, E. C., Fetherston, J. D., and Zimmes, S., 1986, Induction of the cMyc after antigen binding to haptenspecific B cells, J. Exp. Med. 164:944–950
Wade, W. F., Chen, Z. Z., Maki, R., McKercher, S., Palmer, C., Cambier, J. C., and Freed, J. H., 1989, Altered I-A-mediated transmembrane signaling in B cells that express trunscated I-Ak protein, Proc. Natl. Acad. Sci. USA 86:6297–6301
Whalen, B. J., Tony, H.-P., and Parker, D. C., 1988, Characterization of the effector mechanism of help for antigen-presenting and bystander resting B cell growth mediated by Ia-restricted Th2 helper T cell lines, J. Immunol. 141:2230–2239
Yamamoto, K. K., Gonzales, G. A., Biggs, W. H., III, and Montminy, M. R., 1988, Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB, Nature (London) 334:494–498
Zitron, I. M., and Clevinger, B. L., 1980, Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti--δ-antibody that induce allotype-specific proliferation, J. Exp. Med. 152:1135–1146
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Cambier, J.C., Lehmann, K.L., Wade, W.F. (1991). Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation. In: Harris, J.R. (eds) Blood Cell Biochemistry Volume 3. Blood Cell Biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3796-0_4
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3796-0_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6692-8
Online ISBN: 978-1-4615-3796-0
eBook Packages: Springer Book Archive