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Immunobiology of Paramyxoviruses

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The Paramyxoviruses

Part of the book series: The Viruses ((VIRS))

Abstract

This chapter discusses the dissection of structural—functional properties of virus components by immunological methods. Monoclonal antibodies and antipeptide reagents represent remarkable tools for such ventures. Structural and nonstructural proteins of viruses can be identified and purified. Each protein species can be mapped with regard to the different antigenic sites it may expose. In cases when the protein, either isolated or participating in a more complex structure, carries a measurable biological activity, such as hemagglutination or a catalytic function, the involvement of each site of the folded protein in the activity can be evaluated. Sometimes it is possible to correlate variations in biological functions with substitution of a single amino acid.

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  1. Department of Virology, Karolinska Institute, School of Medicine, S-105 21, Stockholm, Sweden

    Erling Norrby

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  1. Howard Hughes Medical Institute, Bethesda, Maryland, USA

    David W. Kingsbury

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Norrby, E. (1991). Immunobiology of Paramyxoviruses. In: Kingsbury, D.W. (eds) The Paramyxoviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3790-8_18

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