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The Paramyxoviruses pp 275–298Cite as

Deletion Mutants of Paramyxoviruses

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Part of the book series: The Viruses ((VIRS))

Abstract

Defective-interfering (DI) particles represent a class of virus deletion mutants that require coinfecting, nondefective, homologous (standard) helper virus to survive. In turn, DI particles usually interfere with the reproduction of the helper virus. These mutants arise spontaneously and are amplified to detectable levels by repeated passage of virus stocks at high multiplicities of infection. They were first described in influenza virus infections by von Magnus (1952), who called them “incomplete viruses,” and this terminology was generally applied to other examples of spontaneously generated noninfectious viruses until Huang and Baltimore (1970) coined the designation “DI particles.”

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Authors and Affiliations

  1. Pediatric Leukemia Research Program, Division of Pediatrics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030, USA

    Gian Guido Re

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  1. Gian Guido Re
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  1. Howard Hughes Medical Institute, Bethesda, Maryland, USA

    David W. Kingsbury

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Re, G.G. (1991). Deletion Mutants of Paramyxoviruses. In: Kingsbury, D.W. (eds) The Paramyxoviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3790-8_10

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  • DOI: https://doi.org/10.1007/978-1-4615-3790-8_10

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