Skip to main content
SpringerLink
Log in

Some Collective Phenomena in the Hippocampus in Vitro

  • Chapter
Self-Organization, Emerging Properties, and Learning

Part of the book series: NATO ASI Series ((NSSB,volume 260))

  • 120 Accesses

Abstract

In this chapter, we shall discuss the structure of one part of the guinea-pig hippocampus, the anatomically simplest type of cortex. We shall describe how the structure of this part (the CA3 region) leads to the existence of a repertoire of different modes of population activity. Selection of a particular mode of population behavior depends on the settings of various functional parameters such as the conductances of the inhibitory synapses. Some of the population activities observed in vitro and in models of the slice appear to have in vivo analogs. We shall tabulate some of the mechanisms which may be available to the brain for setting functional parameters in the hippocampus. Finally, we shall speculate briefly on the behavioral significance of certain population modes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Buzsáki G (1984) Long-term changes of hippocampal sharp-waves following high frequency afferent activation. Brain Res. 300: 179–182.

    Article  PubMed  Google Scholar 

  • Buzsáki G (1986) Hippocampal sharp waves: their origin and significance. Brain Res. 398: 242–252.

    Article  PubMed  Google Scholar 

  • Buzsáki G, Leung L-WS, Vanderwolf CH (1983) Cellular bases of hippocampal EEG in the behaving rat. Brain Res. Rev. 6: 139–171.

    Article  Google Scholar 

  • Christian EP, Dudek FE (1988b) Electrophysiological evidence from glutamate microapplications for local excitatory circuits in the CA1 area of rat hippocampal slices. J. Neurophysiol. 59: 110–123.

    PubMed  CAS  Google Scholar 

  • Collingridge GL, Gage PW, Robertson B (1984) Inhibitory post-synaptic currents in rat hippocampal CA1 neurones. J. Physiol. 356: 551–564.

    PubMed  CAS  Google Scholar 

  • Colmers WF, Lukowiak K, Pittman QJ (1987) Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice. J. Physiol. 383: 285–299.

    PubMed  CAS  Google Scholar 

  • Davies CH, Davies SN, Collingridge GL (1990) Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J. Physiol. 424: 513–531.

    PubMed  CAS  Google Scholar 

  • Edwards FA, Konnerth A, Sakmann B, Takahashi T (1989) A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflüg. Arch. 414: 600–612.

    Article  CAS  Google Scholar 

  • Forsythe ID, Westbrook GL (1988) Slow excitatory postsynaptic currents mediated by N-methyl-D aspartate receptors on cultured mouse central neurones. J. Physiol. 396: 515–533.

    PubMed  CAS  Google Scholar 

  • Freund TF, Antal M (1988) GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus. Nature 336: 170–173.

    Article  PubMed  CAS  Google Scholar 

  • Hablitz JJ (1984) Picrotoxin-induced epileptiform activity in the hippocampus: role of endogenous versus synaptic factors. J. Neurophysiol. 51: 1011–1027.

    PubMed  CAS  Google Scholar 

  • Hablitz JJ, Thalmann RH (1987) Conductance changes underlying a late synaptic hyperpolarization in hippocampal CA3 neurons. J. Neurophysiol. 58: 160–179.

    PubMed  CAS  Google Scholar 

  • Kawaguchi Y, Hama K (1988) Physiological heterogeneity of nonpyramidal cells in rat hippocampal CA1 region. Exp. Brain Res. 72: 494–502.

    Article  PubMed  CAS  Google Scholar 

  • Kay AR, Wong RKS (1986) Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems. J. Neurosci. Meth. 16: 227–238.

    Article  CAS  Google Scholar 

  • Knowles WD, Schwartzkroin PA (1981) Local circuit synaptic interactions in hippocampal brain slices. J. Neurosci. 1: 318–322.

    PubMed  CAS  Google Scholar 

  • Korn SJ, Giacchino JL, Chamberlin NL, Dingledine R (1987) Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition. J. Neurophysiol. 57, 325–340.

    PubMed  CAS  Google Scholar 

  • Lacaille J-C, Mueller AL, Kunkel DD, Schwartzkroin PA (1987) Local circuit interactions between oriens/alveus interneurons and CA1 pyramidal cells in hippocampal slices: electrophysiology and morphology. J. Neurosci. 7: 1979–1993.

    PubMed  CAS  Google Scholar 

  • Lacaille J-C, Schwartzkroin PA (1988a) Stratum lacunosum-moleculare interneurons of hippocampal CA1 region. I. Intracellular response characteristics, synaptic responses, and morphology. J. Neurosci. 8: 1400–1410.

    PubMed  CAS  Google Scholar 

  • Lacaille J-C, Schwartzkroin PA (1988b) Stratum lacunosum-moleculare interneurons of hippocampal CA1 region.II. Intrasomatic and intradendritic recordings of local circuit synaptic interactions. J. Neurosci. 8: 1411–1424.

    PubMed  CAS  Google Scholar 

  • Leung L-WS, Borst JGG (1987) Electrical activity of the cingulate cortex. I. Generating mechanisms and relations to behavior. Brain Res. 407: 68–80.

    Article  PubMed  CAS  Google Scholar 

  • Leung L-WS, Yim CY (1988) Membrane potential osciallations in hippocampal neurons in vitro induced by carbachol or depolarizing currents. Neurosci. Res. Comm. 2: 159–167.

    Google Scholar 

  • MacVicar BA, Tse FW (1989) Local neuronal circuitry underlying cholinergic rhythmical slow activity in CA3 area of rat hippocampal slices. J. Physiol. 417: 197–212.

    PubMed  CAS  Google Scholar 

  • Madison DV, Nicoll RA (1988) Enkephalin hyperpolarizes interneurones in the rat hippocampus. J. Physiol. 398: 123–130.

    PubMed  CAS  Google Scholar 

  • Masukawa LM, Prince DA (1982) Enkephalin inhibition of inhibitory input to CA1 and CA3 pyramidal neurons in the hippocampus. Brain Res. 249: 271–280.

    Article  PubMed  CAS  Google Scholar 

  • Mayer ML, Westbrook GL, Guthrie PB (1984) Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309: 261–263.

    Article  PubMed  CAS  Google Scholar 

  • McCormick DA, Prince DA (1986) Mechanisms of action of acetylcholine in the guinea-pig cerebral cortex in vitro. J. Physiol. 375: 169–194.

    PubMed  CAS  Google Scholar 

  • Mesher RA, Schwartzkroin PA (1980) Can CA3 epileptiform burst discharge induce bursting in normal CA1 hippocampal neurons? Brain Res. 183: 472–476.

    Article  PubMed  CAS  Google Scholar 

  • Miles R (1990) Synaptic excitation of inhibitory cells by single CA3 hippocampal pyramidal cells of the guinea-pig in vitro. J. Physiol.

    Google Scholar 

  • Miles R (In prep.) Variation in strength of inhibitory synapses in the CA3 region of guinea-pig hippocampus in vitro.

    Google Scholar 

  • Miles R, Traub RD, Wong RKS (1988) Spread of synchronous firing in longitudinal slices from the CA3 region of the hippocampus. J. Neurophysiol. 60: 1481–1496.

    PubMed  CAS  Google Scholar 

  • Miles R, Wong RKS (1983) Single neurones can initiate synchronized population discharge in the hippocampus. Nature 306: 371–373.

    Article  PubMed  CAS  Google Scholar 

  • Miles R, Wong RKS (1984) Unitary inhibitory synaptic potentials in the guinea-pig hippocampus in vitro. J. Physiol. 356: 97–113.

    PubMed  CAS  Google Scholar 

  • Miles R, Wong RKS (1986) Excitatory synaptic interactions between CA3 neurones in the guinea-pig hippocampus. J. Physiol. 373: 397–418.

    PubMed  CAS  Google Scholar 

  • Miles R, Wong RKS (1987a) Inhibitory control of local excitatory circuits in the guinea-pig hippocampus. J. Physiol. 388: 611–629.

    PubMed  CAS  Google Scholar 

  • Miles R, Wong RKS (1987b) Latent synaptic pathways revealed after tetanic stimulation in the hippocampus. Nature 329: 724–726.

    Article  PubMed  CAS  Google Scholar 

  • Miles R, Wong RKS, Traub RD (1984) Synchronized afterdischarges in the hippocampus: contribution of local synaptic interaction. Neuroscience 12: 1179–1189.

    Article  PubMed  CAS  Google Scholar 

  • Nicoll RA (1988) The coupling of neurotransmitter receptors to ion channels in the brain. Science 241: 545–551.

    Article  PubMed  CAS  Google Scholar 

  • Regehr WG, Connor JA, Tank DW (1989) Optical imaging of calcium accumulation in hippocampal pyramidal cells during synaptic activation. Nature 341: 533–536.

    Article  PubMed  CAS  Google Scholar 

  • Ross WN, Werman R (1987) Mapping calcium transients in the dendrites of Purkinje cells from the guinea-pig cerebellum in vitro. J. Physiol. 389: 319–336.

    PubMed  CAS  Google Scholar 

  • Sayer RJ, Friedlander MJ, Redman SJ (1990) The time course and amplitude of EPSPs evoked at synapses between pairs of CA3/CA1 neurons in the hippocampal slice. J. Neurosci. 10: 826–836.

    PubMed  CAS  Google Scholar 

  • Scharfman HE, Schwartzkroin PA (1989) Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices. Brain Res. 493: 205–211.

    Article  PubMed  CAS  Google Scholar 

  • Schneiderman JH (1986) Low concentrations of penicillin reveal rhythmic, synchronous synaptic potentials in hippocampal slice. Brain Res. 398: 231–241.

    Article  PubMed  CAS  Google Scholar 

  • Schwartzkroin PA (1978) Secondary range rhythmic spiking in hippocampal neurons. Brain Res. 149: 247–250.

    Article  PubMed  CAS  Google Scholar 

  • Schwartzkroin PA, Haglund MM (1986) Spontaneous rhythmic synchronous activity in epileptic human and normal monkey temporal lobe. Epilepsia 27: 523–533.

    Article  PubMed  CAS  Google Scholar 

  • Schwartzkroin PA, Knowles WD (1984) Intracellular study of human epileptic cortex: in vitro maintenance of epileptiform activity: Science 223: 709–712.

    Article  PubMed  CAS  Google Scholar 

  • Schwartzkroin PA, Mathers LH (1978) Physiological and morphological identification of a nonpyramidal hippocampal cell type. Brain Res. 157: 1–10.

    Article  PubMed  CAS  Google Scholar 

  • Stelzer A, Kay A, Wong RKS (1988) GABAA receptor function in hippocampal cells is maintained by phosphorylation factors. Science 241: 339–341.

    Article  PubMed  CAS  Google Scholar 

  • Swann JW, Smith KL, Brady RJ (in press) Neural networks and synaptic transmission in immature hippocampus. In: Ben-Ari Y, ed., Excitatory Amino Acids and Neuronal Plasticity. Advances in Experimental Medicine and Biology. Plenum Press.

    Google Scholar 

  • Traub RD, Miles R (1991) Neuronal Networks of the Hippocampus, Cambridge University Press.

    Google Scholar 

  • Traub RD, Miles R, Wong RKS (1989) Model of the origin of rhythmic population oscillations in the hippocampal slice. Science 243: 1319–1325.

    Article  PubMed  CAS  Google Scholar 

  • Traub RD, Wong RKS, Miles R (1990) A model of the CA3 hippocampal pyramidal cell based on voltage-clamp data. Abstr. Soc. Neurosci.

    Google Scholar 

  • Traub RD, Miles R (in press) Multiple modes of neuronal population activity emerge after modifying specific synapses in a model of the CA3 region of the hippocampus. In: Wolpaw JR, Schmidt JT, eds., Activity-driven CNS Changes in Learning and Development, NY Acad. Sci.

    Google Scholar 

  • Wigström H, Gustafsson B (1983) Facilitated induction of hippocampal longlasting potentiation during blockade of inhibition. Nature 301: 603–604.

    Article  PubMed  Google Scholar 

  • Wong RKS, Prince DA (1981) Afterpotential generation in hippocampal pyramidal cells, J. Neurophysiol. 45: 86–97.

    PubMed  CAS  Google Scholar 

  • Wong RKS, Prince DA, Basbaum Al (1979) Intradendritic recordings from hippocampal neurons. Proc. Nat. Acad. Sci. 76: 986–990.

    Article  PubMed  CAS  Google Scholar 

  • Wong RKS, Traub RD (1983) Synchronized burst discharge in disinhibited hippocampal slice. I. Initiation in CA2-CA3 region. J. Neurophysiol. 49: 442–458.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. IBM Research Division, Thomas J. Watson Research Center, Yorktown Heights, NY, 10598, USA

    Roger D. Traub

  2. Institut Pasteur, Laboratoire de Neurobiologie Cellulaire, 28 Rue du Dr. Roux, 75724, Paris Cedex 15, France

    Richard Miles

Authors
  1. Roger D. Traub
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard Miles
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Free University of Brussels, Brussels, Belgium

    Agnessa Babloyantz

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Traub, R.D., Miles, R. (1991). Some Collective Phenomena in the Hippocampus in Vitro. In: Babloyantz, A. (eds) Self-Organization, Emerging Properties, and Learning. NATO ASI Series, vol 260. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3778-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3778-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6684-3

  • Online ISBN: 978-1-4615-3778-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation