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Fibronectin and Other Cell Interactive Glycoproteins

  • Chapter
Cell Biology of Extracellular Matrix

Abstract

Fibronectin, laminin, and other recently characterized noncollagenous extra-cellular proteins play important roles in many cell surface interactions. For example, fibronectin helps to mediate cell adhesion, embryonic cell migration, and wound healing, while laminin can promote processes as diverse as axonal outgrowth, maintenance of the polarized, differentiated phenotype of epithelial cells on a basement membrane, and metastasis. Each of these glycoproteins can participate in a variety of functions by using different specialized domains or peptide recognition sequences for binding to specific cell surface receptors, or to collagens, proteoglycans, or other extracellular molecules. In the decade since the first edition of this book, there has been remarkable progress in our understanding of the structures, domain organization, and biological roles of these multifunctional cell interactive proteins.

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  1. Laboratory of Development Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Kenneth M. Yamada

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  1. Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Elizabeth D. Hay

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Yamada, K.M. (1991). Fibronectin and Other Cell Interactive Glycoproteins. In: Hay, E.D. (eds) Cell Biology of Extracellular Matrix. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3770-0_5

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  • DOI: https://doi.org/10.1007/978-1-4615-3770-0_5

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