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Selective Activation of Drugs by Redox Processes pp 295–302Cite as

Bioreductive Drugs and Radiation: Pharmacokinetics and Clinical Trials of Etanidazole Radiosensitizer

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Part of the book series: NATO ASI Series ((NSSA,volume 198))

Abstract

One of the biggest problems in recurrence of tumour is the resistance of hypoxic cells1,2. Radiosensitizing drugs, such as metronidazole, misonidazole, etanidazoie and recently pimonidazole have been tested clinically in the last 15 years to improve the sensitization of the hypoxic cells. At present clinical trials are underway mainly with etanidazoie because of the strong neuropathic side effects of the other nitroimidazole derivatives3.

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References

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Author information

Authors and Affiliations

  1. Divisione di Radioterapia, Ospedale Malpighi, Bologna Istituto di Scienze Chimiche, Universita’ degli Studi di Bologna, Italy

    L. Busutti, A. Petralia, A. Breccia & E. Ferri

Authors
  1. L. Busutti
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  2. A. Petralia
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  3. A. Breccia
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  4. E. Ferri
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Editor information

Editors and Affiliations

  1. MRC Radiobiology Unit, Didcot, Chilton, Oxon., OX11 ORD, UK

    G. E. Adams  & E. M. Fielden  & 

  2. Facoltà di Farmacia, Istituto di Scienze Chimiche, Università Degli Studi di Bologna, 40127, Bologna, Via S. Donato, 15, Italy

    A. Breccia

  3. CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, UK

    P. Wardman

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© 1990 Springer Science+Business Media New York

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Busutti, L., Petralia, A., Breccia, A., Ferri, E. (1990). Bioreductive Drugs and Radiation: Pharmacokinetics and Clinical Trials of Etanidazole Radiosensitizer. In: Adams, G.E., Breccia, A., Fielden, E.M., Wardman, P. (eds) Selective Activation of Drugs by Redox Processes. NATO ASI Series, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3768-7_27

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  • DOI: https://doi.org/10.1007/978-1-4615-3768-7_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6679-9

  • Online ISBN: 978-1-4615-3768-7

  • eBook Packages: Springer Book Archive

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