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Fluorescent Probes for Hypoxia: Chemical Aspects

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Selective Activation of Drugs by Redox Processes

Part of the book series: NATO ASI Series ((NSSA,volume 198))

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Abstract

The presence of hypoxic cells in solid tumours and the potential significance of this for the long term efficacy of the radiotherapy of solid tumours has been recognised for over 30 years1. However, progress in the development of methods capable of giving visual evidence of the presence of hypoxic cells and the location of these cells within the tumour, together with a quantitative estimation of the extent of hypoxia, have been made only in the last decade. Of particular importance in this connection are experimental results which have shown that at least part of the molecule of the 2-nitroimidazole radiosensitizer, misonidazole (MISO) (1) is bound into hypoxic cells by metabolic processes and/or upon irradiation2; that certain 2-nitrofuran derivatives suffer a similar fate upon metabolism in hypoxic cells3; and that the kinetics of incorporation and patterns of distribution of the 2-C atom and the 2’-H atom of misonidazole in hypoxic cells are identical4.

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References

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Author information

Authors and Affiliations

  1. Chemistry Department, Brunel University, Uxbridge, Middlesex, UK

    John Parrick, Gareth W. Jones, Richard W. Middleton & Harshad K. Rami

  2. The Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK

    Richard J. Hodgkiss & Peter Wardman

Authors
  1. John Parrick
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  2. Richard J. Hodgkiss
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  3. Gareth W. Jones
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  4. Richard W. Middleton
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  5. Harshad K. Rami
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  6. Peter Wardman
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Editor information

Editors and Affiliations

  1. MRC Radiobiology Unit, Didcot, Chilton, Oxon., OX11 ORD, UK

    G. E. Adams  & E. M. Fielden  & 

  2. Facoltà di Farmacia, Istituto di Scienze Chimiche, Università Degli Studi di Bologna, 40127, Bologna, Via S. Donato, 15, Italy

    A. Breccia

  3. CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, UK

    P. Wardman

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© 1990 Springer Science+Business Media New York

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Parrick, J., Hodgkiss, R.J., Jones, G.W., Middleton, R.W., Rami, H.K., Wardman, P. (1990). Fluorescent Probes for Hypoxia: Chemical Aspects. In: Adams, G.E., Breccia, A., Fielden, E.M., Wardman, P. (eds) Selective Activation of Drugs by Redox Processes. NATO ASI Series, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3768-7_23

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  • DOI: https://doi.org/10.1007/978-1-4615-3768-7_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6679-9

  • Online ISBN: 978-1-4615-3768-7

  • eBook Packages: Springer Book Archive

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