Abstract
The interest in the use of hypoxic cell sensitizers for tumor therapy is based upon their radiosensitizing and cytotoxic effects on hypoxic cells1 as well as their chemosensitization of cytotoxic drugs. The clinical use of these sensitizers has been severely limited by their neurotoxicity in patients2. Comparatively little is known about the molecular and metabolic processes which are responsible for the development of the cytotoxic and neurotoxic effects. In our laboratory glucose metabolism and gluthathione levels have been studied in normal tissues and tumors of mice after treatment with hypoxic cell sensitizers.
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Streffer, C., Tamulevicius, P. (1990). Metabolic Effects of Hypoxic Cell Sensitizers. In: Adams, G.E., Breccia, A., Fielden, E.M., Wardman, P. (eds) Selective Activation of Drugs by Redox Processes. NATO ASI Series, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3768-7_14
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DOI: https://doi.org/10.1007/978-1-4615-3768-7_14
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