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Molecular Interactions and Biological Effects of the Products of Reduction of Nitroimidazoles

  • Chapter
Selective Activation of Drugs by Redox Processes

Part of the book series: NATO ASI Series ((NSSA,volume 198))

Abstract

“Bioreductive drugs” exhibit selective toxicity towards hypoxic cells, a property of potential use in cancer therapy due to the presence of hypoxic regions in solid tumours. The model for the action of these drugs involves metabolic reduction, with some species produced by that reduction being biologically active. The selectivity arises since high concentrations of oxygen inhibit reduction, the one electron reduction product transferring its extra electron O2 and reverting back to parent drug1.

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of Toronto, Toronto, Ontario, Canada

    Robert A. McClelland

Authors
  1. Robert A. McClelland
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Editor information

Editors and Affiliations

  1. MRC Radiobiology Unit, Didcot, Chilton, Oxon., OX11 ORD, UK

    G. E. Adams  & E. M. Fielden  & 

  2. Facoltà di Farmacia, Istituto di Scienze Chimiche, Università Degli Studi di Bologna, 40127, Bologna, Via S. Donato, 15, Italy

    A. Breccia

  3. CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, UK

    P. Wardman

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© 1990 Springer Science+Business Media New York

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McClelland, R.A. (1990). Molecular Interactions and Biological Effects of the Products of Reduction of Nitroimidazoles. In: Adams, G.E., Breccia, A., Fielden, E.M., Wardman, P. (eds) Selective Activation of Drugs by Redox Processes. NATO ASI Series, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3768-7_11

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  • DOI: https://doi.org/10.1007/978-1-4615-3768-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6679-9

  • Online ISBN: 978-1-4615-3768-7

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