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Monitoring and Imaging of Tissue Blood Flow by Coherent Light Scattering

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Optronic Techniques in Diagnostic and Therapeutic Medicine

Abstract

Monitoring and visualization of tissue perfusion have for a long time been an intriguing task both to the medical scientist wanting to explore the basic nature of microcirculation and the clinical practitioner diagnosing diseases known to affect peripheral circulation. Because of the extreme sensitivity of the microvascular network to almost any kind of stimuli, methods designed for these purposes must be based on principles that do not influence tissue perfusion. Measurement principles utilizing the interaction of light and perfused tissue have been successfully used for the recording of changes in microvascular blood volume (Challoner, 1979) and tissue oxygenization (Tremper and Baker, 1989). Laser Doppler flowmetry (LDF), a technique intended for the direct recording of tissue perfusion, is based on the fact that photons undergo a frequency shift according to the Doppler principle when scattered by a moving object such as a blood cell (Holloway and Watkins, 1977, Nilsson et. al. 1980a, b).

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References

  • Challoner, A.V. J., 1979, Photoelectric plethysmography for estimating cutaneous blood flow, in: “Non-Invasive Physiological Measurements”, Vol 1., P. Rolfe, ed., Academic Press.

    Google Scholar 

  • Tremper, K.K. and Barker, S.J., Pulse Oximetry, 1989, Anesthesiology, 70:98.

    Article  Google Scholar 

  • Holloway, G.A. and Watkins, D.W., 1977, Laser Doppler measurement of cutaneous blood flow, J. Invest Dermatol, 69:306.

    Article  Google Scholar 

  • Nilsson, G.E., Tenland, T. and Öberg, P.Å., A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy, 1980a, IEEE Trans., BME-27:12.

    Google Scholar 

  • Nilsson, G.E., Tenland, T. and Öberg, P.Å., 1980b, Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow, IEEE Trans., BME-27:597.

    Google Scholar 

  • Stern, M.D., In vivo evaluation of microcirculation by coherent light scattering, 1975, Nature, 254:56.

    Article  ADS  Google Scholar 

  • Van Gemert, M.J.C., Jacques, S.L., Sterenborg, H.J.C.M. and Star, W.M., 1989, Skin optics, IEEE Trans., BME-36:1146.

    Google Scholar 

  • Jakobsson, A. and Nilsson, G.E., 1990, A Monte Carlo model for simulation of light scattering in laser Doppler flowmetry, XVI European Conference on Microcirculation, Zurich, August 26–31.

    Google Scholar 

  • Steinke, J.M. and Shepherd, A.P., 1988, Comparison of Mie theory and the light scattering of red blood cells, Appl. Optics, 27:4027.

    Article  ADS  Google Scholar 

  • Nilsson, G.E., 1984, Signal processor for laser Doppler tissue flowmeters, Med. & Biol. Engng. & Comput., 22:343.

    Article  Google Scholar 

  • Ahn, H.C., 1986, Measurement of gastrointestinal blood flow with laser Doppler flowmetry, Linköping University Medical Dissertation No. 226, Linköping, Sweden.

    Google Scholar 

  • Salerud, E.G and Nilsson, G.E., 1986, Integrating probe for tissue laser Doppler flowmeters, Med. & Biol. Engng. & Comput., 24:415.

    Article  Google Scholar 

  • Salerud, E.G. and Öberg, P.Å., 1987, Single-fibre laser Doppler flowmetry: A method for deep tissue perfusion studies, Med. & Biol. Engng. & Comput., 25:329.

    Article  Google Scholar 

  • Kvernebo, K. and Salerud, E.G., 1987, Single fibre laser Doppler flowmetry in the evaluation of human muscle blood flow, Fourth World Congress for Microcirculation, Tokyo, Japan, July 26–30.

    Google Scholar 

  • Nilsson, G.E., 1989, Perimed’s laser Doppler blood flowmeter, In: “Laser Doppler Blood Flowmetry”, P. Shepherd and P.Å. Öberg, eds., Kluwer Academic Publishers (in press).

    Google Scholar 

  • de Mul, F.F.M., van Spijker, J., van der Plas, D., Greve, J., Aarnoudse, J.G. and Smits, T.M., 1984, Mini laser Doppler (blood) flow monitor with diode laser source and detection integrated in the probe, Applied Optics, 23:2970.

    Article  ADS  Google Scholar 

  • Bonner, R. and Nossal, R., 1981, Model for laser Doppler measurements of blood flow in tissue, Appl. Optics, 20:2097.

    Article  ADS  Google Scholar 

  • Ahn, H., Lindhagen, J., Nilsson, G.E., Salerud, E.G., Jodal, M. and Lundgren, O., 1985, Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat, Gastroenterology, 88:951.

    Google Scholar 

  • Ahn. H., Johansson, K., Lundgren, O. and Nilsson, G.E., 1987, In vivo evaluation of signal processors for laser Doppler tissue flowmeters, Med. & Biol. Engng. & Comput., 25:207.

    Article  Google Scholar 

  • Perimed Literature Reference List No 9. Perimed AB, Stockholm, Sweden, 1989.

    Google Scholar 

  • Nilsson, G.E., Otto, U. and Wahlberg, J.E., 1982, Assessment of skin irritancy in man by laser Doppler flowmetry, Contact Dermatitis, 8:401.

    Article  Google Scholar 

  • Svensson, H. and Svedman, P., 1982, On postoperative monitoring of the circulation in flaps, Int. J. Microcirc.: Clin. & Exp., 1:326.

    Google Scholar 

  • Jones, B. and Mayou, B.J., 1982, The laser Doppler flowmeter for microvascular monitoring: a preliminary report, Brit. J. Plast. Surg., 35:147.

    Article  Google Scholar 

  • Jenkins, S., Sepka, R. and Barwick, W.J., 1988, Routine use of laser Doppler flowmetry for monitoring autologous tissue transplants, Ann. Plast. Surg., 21(5):423.

    Article  Google Scholar 

  • Kvernebo, K., Lunde O.C., Stranden E. and Larsen, S., 1986, Human gastric blood circulation evaluated by endoscopic laser Doppler flowmetry, Scand. J. Gastroenterol., 21:6851.

    Article  Google Scholar 

  • Lunde, O.C. and Kvernebo, K., 1988, Gastric blood flow in patients with gastric ulcer measured by endoscopic laser Doppler flowmetry, Scand. J. Gastroenterol., 23:546.

    Article  Google Scholar 

  • Johansson, K., 1988, Gastrointestinal application of laser Doppler flowmetry, Thesis No.269, Linköping University.

    Google Scholar 

  • Ahn, H.C., Ekroth, R., Nilsson, G.E. and Svedjeholm, R., 1988a, Assessment of myocardial perfusion with laser Doppler flowmetry, Scand. J. Thor. Cardiovascular. Surg., 22:45.

    Google Scholar 

  • Ahn, H., Ekroth, R., Hedemark, J., Nilsson, G.E. and Svedjeholm, R., 1988b, Assessment of myocardial perfusion in the empty beating porcine heart with laser Doppler flowmetry, Cardiovascular Research, 22:719.

    Article  Google Scholar 

  • Ahn, H.C., Ekroth, R., Nilsson, G.E., Svedjeholm, R. and Thelin, S., 1988c, Laser Doppler flowmetry estimating myocardial perfusion after internal mammary grafting, Scand. J. Thor. Cardiovasc. Surg., 22:281.

    Article  Google Scholar 

  • Arbit, E., DiResta, G.R., Bedford, R.F., Shah, N.K. and Galicich, J.H., 1989. Intraoperative measurement of cerebral and tumor blood flow with laser-Doppler flowmetry, Neurosurgery, 24:166.

    Article  Google Scholar 

  • Fasano, V.A., Urciuoli, R., Bolognese, P. and Mostert, M., 1988, Intraoperative use of laser Doppler in the study of cerebral microvascular circulation, Acta Neurochir. (Wien), 95:40.

    Article  Google Scholar 

  • Schlehr, F.J., Limbird, T.A., Swiontkowski, M.F. and Keller, T.S., 1987, The use of laser Doppler flowmetry to evaluate anterior cruciate blood flow, J. Orthop. Res., 5:150.

    Article  Google Scholar 

  • O’Reilly, Spence R.J., Taylor, R.M. and Scheulen, J.J., 1989, Laser Doppler flowmetry evaluation of burn wound depth, J. Burn. Care. Rehabil., 10:1.

    Article  Google Scholar 

  • Wollerheim, H., Reyenga, J. and Thien, T., 1988, Laser Doppler velocimetry of fingertips during heat provocation in normals and in patients with Raynaud’s phenomenon, Scand. J. Clin. Lab. Invest., 48:91.

    Google Scholar 

  • Bunker, C.B., Lanigan, S., Rustin, M.H. and Dowd, P.M., 1988, The effects of topically applied hexil nicotinate lotion on the cutaneous blood flow in patients with Raynaud’s phenomenon, Br. J. Dermatol., 119:771.

    Article  Google Scholar 

  • Ekenwall, L., Lindblad, L.E., Carlsson, A. and Etzell, B.M., 1988, Afferent and efferent nerve injury in vibration white fingers, J. Auton. Nerve. Syst., 24:261.

    Article  Google Scholar 

  • Tooke, J.E., Lins, P.E., Östergren, J., Adamson, U. and Fagrell, B., 1985, The effects of intravenous insulin infusion on skin microcirculatory flow in type 1 diabetes, Int. J. Microcirc.: Clin. Exp. 4:69.

    Google Scholar 

  • Rayman, G., Hassan, A. and Tooke, J.E., 1986, Blood flow in the skin of the foot related to posture in diabetes mellitus, Brit. Med. J., 292:87.

    Article  Google Scholar 

  • Newrick, P.G., Cochrane, T., Betts, R.P., Ward, J.D. and Boulton, A.J., 1988, Reduced hyperaemic response under the diabetic neuropathic foot, Diabetic Med., 5:570.

    Article  Google Scholar 

  • Nilsson, G.E., Jakobsson, A. and Wårdell, K., 1989, Imaging of tissue blood flow by coherent light scattering, IEEE 11th Ann EMBS Conference Proc., Seattle, Nov 9–12.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Biomedical Instrumentation, Department of Biomedical Engineering, Linköping University, Linköping, Sweden

    Gert E. Nilsson, Anneli Jakobsson & Karin Wårdell

Authors
  1. Gert E. Nilsson
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  2. Anneli Jakobsson
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  3. Karin Wårdell
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Editor information

Editors and Affiliations

  1. Institute of Quantum Electronics and Department of Physics, Florence, Italy

    Riccardo Pratesi

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© 1991 Springer Science+Business Media New York

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Nilsson, G.E., Jakobsson, A., Wårdell, K. (1991). Monitoring and Imaging of Tissue Blood Flow by Coherent Light Scattering. In: Pratesi, R. (eds) Optronic Techniques in Diagnostic and Therapeutic Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3766-3_7

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  • DOI: https://doi.org/10.1007/978-1-4615-3766-3_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6678-2

  • Online ISBN: 978-1-4615-3766-3

  • eBook Packages: Springer Book Archive

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