Abstract
Photodynamic therapy (PDT) is a selective, experimental treatment for solid tumors. PDT consists of the activation of a photosensitizing agent by light. The photodynamic reaction induced by light causes damage to the tissue containing the photosensitizer in the presence of oxygen. The idea of treating tumors by photosensitizers is as old as the early 1900s; already in 1903, topic application of eosin and exposition to sunlight was known to produce a response in skin tumors. Later, in 1924, Policard reported reddish fluorescence in animal and human tumors observed under Wood lamp. The presence of fluorescence was attributed to endogenous porphyrins accumulated after infection of the observed tissue by hemolytic bacteria.2 In 1942, Auler and Banzer3 reported animal tumor fluorescence after systemic administration of Hematoporphyrin (HP) and in 1960 Lipson and coworkers prepared the Hematoporphyrine derivative (HPD), a mixture of porphyrins obtained by treating HP with acetic and sulphuric acids.4 They demonstrated that HPD was selectively accumulated by malignant as well as by actively proliferating tissues and produced the first demonstration of endoscopic diagnosis of malignant tissues by detection of fluorescence in the respiratory and in the upper digestive tract.5 After the development of the laser, diagnosis through fluorescence and particularly PDT have been studied further.
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Spinelli, P., Dal Fante, M., Mancini, A. (1991). Laserchemotherapy of Tumours: Clinical Aspects. In: Pratesi, R. (eds) Optronic Techniques in Diagnostic and Therapeutic Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3766-3_20
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DOI: https://doi.org/10.1007/978-1-4615-3766-3_20
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