Abstract
A variety of solid tumours, having different histological and optical properties, have been shown to be responsive to photodynamic therapy (PDT) and this technique is presently under investigation in several clinical centers.1 Promising results have been obtained especially in the treatment of bladder2 and lung3 cancers, as well as in the detection and therapy of early squamous cell carcinomas of the pharynx, oesophagus and tracheo-bronchial tree.4 In spite of such diversified applications, PDT is still in a developing stage mainly owing to the scarcity of information on its mechanism of action and the interplay of different factors controlling the efficacy and safety of the technique. Thus, the two parameters which should ensure the selectivity of PDT for malignant tissues, i.e. the larger accumulation and longer retention of the systemically injected photosensitizer by tumours as compared with peritumoural tissues, and the degree of light propagation through biological tissue layers, appear to be quite complex problems and are poorly defined.
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Jori, G., Reddi, E. (1991). Photochemiotherapy of Tumours: Molecular and Biophysical Bases. In: Pratesi, R. (eds) Optronic Techniques in Diagnostic and Therapeutic Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3766-3_19
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DOI: https://doi.org/10.1007/978-1-4615-3766-3_19
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